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是否应建议这位慢性阻塞性肺疾病患者使用吸入性皮质类固醇?:贝斯以色列女执事医疗中心的大查房讨论。

Should You Recommend Inhaled Corticosteroids for This Patient With Chronic Obstructive Pulmonary Disease?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center.

机构信息

Beth Israel Deaconess Medical Center, Boston, Massachusetts (R.B.B., A.A., M.B.R., G.W.S.).

出版信息

Ann Intern Med. 2020 Jun 2;172(11):735-742. doi: 10.7326/M20-1058.

Abstract

Approximately 12 million adults in the United States receive a diagnosis of chronic obstructive pulmonary disease (COPD) each year, and it is the fourth leading cause of death. refers to a group of diseases that cause airflow obstruction and a constellation of symptoms, including cough, sputum production, and shortness of breath. The main risk factor for COPD is tobacco smoke, but other environmental exposures also may contribute. The GOLD (Global Initiative for Chronic Obstructive Lung Disease) 2020 Report aims to provide a nonbiased review of the current evidence for the assessment, diagnosis, and treatment of patients with COPD. To date, no conclusive evidence exists that any existing medications for COPD modify mortality. The mainstay of treatment for COPD is inhaled bronchodilators, whereas the role of inhaled corticosteroids is less clear. Inhaled corticosteroids have substantial risks, including an increased risk for pneumonia. Here, 2 experts, both pulmonologists, reflect on the care of a woman with severe COPD, a 50-pack-year smoking history, frequent COPD exacerbations, and recurrent pneumonia. They consider the indications for inhaled corticosteroids in COPD, when inhaled corticosteroids should be withdrawn, and what other treatments are available.

摘要

美国每年约有 1200 万成年人被诊断为慢性阻塞性肺疾病(COPD),它是第四大致死原因。COPD 是一组可导致气流受限和一系列症状(包括咳嗽、咳痰和呼吸困难)的疾病。COPD 的主要危险因素是烟草烟雾,但其他环境暴露也可能有影响。GOLD(慢性阻塞性肺疾病全球倡议)2020 报告旨在对 COPD 患者评估、诊断和治疗的现有证据进行非偏见性审查。迄今为止,尚无确凿证据表明任何现有的 COPD 药物可降低死亡率。COPD 的主要治疗方法是吸入支气管扩张剂,而吸入皮质类固醇的作用则不太明确。在这里,两位肺病专家回顾了一位患有严重 COPD、有 50 包年吸烟史、频繁 COPD 加重和反复肺炎的女性的治疗情况。他们考虑了 COPD 中使用吸入皮质类固醇的指征、何时应停用吸入皮质类固醇以及有哪些其他治疗方法。

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