Zhang Jian-Qiu, Han Li-Biao
National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8565, Japan.
Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8571, Japan.
Org Lett. 2020 Jun 19;22(12):4633-4637. doi: 10.1021/acs.orglett.0c01384. Epub 2020 Jun 1.
We report a new method for the synthesis of acylphosphine oxides by the direct coupling of hydrogen phosphine oxides and acyl chlorides mediated by chlorosilanes. This new protocol is greener and safer, because it precludes the generation of volatile haloalkanes and the use of oxidants employed in the conventional methods. Moreover, moisture-unstable acylphosphine oxides that are difficult to prepare via the conventional methods can be generated using this new method.
我们报道了一种通过氯硅烷介导的氧化膦与酰氯直接偶联来合成酰基氧化膦的新方法。这种新方法更绿色、更安全，因为它避免了挥发性卤代烃的生成以及传统方法中使用的氧化剂。此外，使用这种新方法可以生成难以通过传统方法制备的对水分不稳定的酰基氧化膦。
