Brain & Behaviour Research Institute and School of Psychology, University of Wollongong, Wollongong, NSW 2522, Australia.
Brain & Behaviour Research Institute and School of Psychology, University of Wollongong, Wollongong, NSW 2522, Australia.
Int J Psychophysiol. 2020 Sep;155:32-40. doi: 10.1016/j.ijpsycho.2020.05.009. Epub 2020 May 30.
The immediately-prestimulus electroencephalographic (EEG) brain state influences subsequent event-related processing, dynamically impacting event-related potential (ERP) and behavioural outcomes. Both EEG and ERPs are known to undergo age-related change, yet few have investigated the consistency in their dynamic interrelations in the context of ageing. The present investigation assessed the impact of prestimulus alpha and beta brain states in 20 young (18-26 years) and 20 gender-matched healthy older (59-75 years) adults who completed an equiprobable auditory Go/NoGo paradigm. Prestimulus alpha and beta band amplitudes in their prominent band topographies were separately used to derive Go and NoGo ERPs at 10 ascending levels of prestimulus activity, and ERP components were derived for these levels using Principal Components Analysis. Prestimulus alpha directly modulated Go/NoGo P3a amplitudes across the groups, while beta inversely modulated the young (cf. older) adult NoGo N1-1, each supporting and extending limited prior research. Several novel effects were also uncovered, most notably an inverse relationship between prestimulus alpha and reaction time. Prestimulus alpha and beta were confirmed as significant determinants of the processing outcomes in this task, and the complex pattern of results provides a normative map in healthy ageing.
即刻刺激前的脑电图 (EEG) 脑状态会影响后续的事件相关处理，从而动态地影响事件相关电位 (ERP) 和行为结果。EEG 和 ERP 都已知会随着年龄的增长而发生变化，但很少有人研究它们在老化背景下的动态相互关系的一致性。本研究评估了刺激前 alpha 和 beta 脑状态对 20 名年轻（18-26 岁）和 20 名性别匹配的健康老年人（59-75 岁）的影响，他们完成了一个等概率的听觉 Go/NoGo 范式。在其主要带地形中分别使用刺激前 alpha 和 beta 频段的幅度来得出 10 个递增的刺激前活动水平的 Go 和 NoGo ERP，并使用主成分分析为这些水平得出 ERP 成分。刺激前 alpha 直接调节了两组的 Go/NoGo P3a 幅度，而 beta 则反向调节了年轻（相比年长）成年人的 NoGo N1-1，这两种调节都支持并扩展了有限的先前研究。还发现了一些新的效应，最显著的是刺激前 alpha 与反应时间之间的反比关系。刺激前 alpha 和 beta 被确认为该任务处理结果的重要决定因素，复杂的结果模式为健康老龄化提供了一个规范图。
