Assogba U, Baumelou A, Pecquinot M A, Raymond F, Durande J P, Lenoir G, Rottembourg J
Service de Néphrologie, Hôpital Pitié-Salpêtrière, Paris.
Ann Med Interne (Paris). 1988;139 Suppl 1:38-9.
Prednisone and prednisolone extraction was determined during seven sessions of plasma exchange in four patients. Each patient received 0.5 mg/kg of prednisone administered orally 2 hours before plasma exchange. Concentrations of prednisone and prednisolone were determined in blood before, every half hour during and at the end of plasma exchange. Both drugs were also determined in removed plasma, mean volume of removed plasma being 0.96 plasmatic mass. The amount of combined prednisone and prednisolone removed by plasma exchange was 1.70% of the administered prednisone dose. This quantity appears minimal and supplemental dosing of prednisone or modification of administration time would seem to be unnecessary.
在对4例患者进行的7次血浆置换过程中，测定了泼尼松和泼尼松龙的清除情况。每位患者在血浆置换前2小时口服0.5mg/kg泼尼松。在血浆置换前、置换过程中每半小时以及置换结束时测定血液中泼尼松和泼尼松龙的浓度。同时也对分离出的血浆进行了这两种药物的测定，分离出的血浆平均量为0.96个血浆量。血浆置换清除的泼尼松和泼尼松龙总量为所给予泼尼松剂量的1.70%。该量似乎很少，似乎无需补充泼尼松剂量或调整给药时间。
