编码补体C5的人类基因定位于9号染色体q22 - 9q33区域。

The assignment of the human gene coding for complement C5 to chromosome 9q22-9q33.

作者信息

Jeremiah S J, West L F, Davis M, Povey S, Carritt B, Fey G H

机构信息

Galton Laboratory, University College London.

出版信息

Ann Hum Genet. 1988 May;52(2):111-6. doi: 10.1111/j.1469-1809.1988.tb01085.x.

DOI:10.1111/j.1469-1809.1988.tb01085.x

PMID:3248005

Abstract

The presence or absence of the human gene for the fifth component of complement (C5) was analysed in 19 human-rodent hybrid cell lines by hybridization to a radiolabelled probe derived from a human C5 cDNA clone. The segregation of C5 in these hybrids suggested that the gene is localized on chromosome 9, in the region 9q21-9qter. In situ hybridization refined the assignment of C5 to chromosome 9q22-33.

摘要

通过与源自人类C5 cDNA克隆的放射性标记探针杂交，分析了19个人类-啮齿动物杂交细胞系中补体第五成分（C5）的人类基因的存在与否。这些杂交体中C5的分离表明该基因定位于9号染色体上9q21 - 9qter区域。原位杂交将C5的定位精确到9号染色体的9q22 - 33区域。