Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China; Department of Thyroid and Breast Surgery, Jining No. 1 People's Hospital, Jining, Shandong, China.
Biomed Pharmacother. 2020 Aug;128:110254. doi: 10.1016/j.biopha.2020.110254. Epub 2020 May 29.
Breast cancer is the leading cause of cancer death among women across the world. Trametes robiniophila Murr (Huaier), a traditional herbal medicine, has been used in China to protect human health for about 1600 years. Recent years, Huaier had been proven to be effective for multiple types of malignancies. This systematic review focused on breast cancer treatment, summarizing the curative function of Huaier aqueous extract and polysaccharides in preclinical researches. Huaier could markedly inhibit breast cancer progression with low toxicity, enhance immune response and increase the sensitivity to radiation and chemotherapy. The therapeutic effect of Huaier granule in clinical studies was also included. This review amalgamated the current studies and highlighted the promising role of Huaier and its polysaccharides as complementary alternative medicine in breast cancer treatment.
乳腺癌是全世界女性癌症死亡的主要原因。瑞香狼毒（Huaier），一种传统的草药，在中国已经被用于保护人类健康约 1600 年。近年来，Huaier 已被证明对多种恶性肿瘤有效。本系统评价主要关注乳腺癌的治疗，总结了 Huaier 水提物和多糖在临床前研究中的治疗作用。Huaier 可以显著抑制乳腺癌的进展，且毒性低，能增强免疫反应，增加对放疗和化疗的敏感性。临床研究中 Huaier 颗粒的治疗效果也包括在内。本综述综合了目前的研究结果，强调了 Huaier 及其多糖作为乳腺癌治疗的补充替代医学的有前景的作用。
