姜黄素载药脂质核纳米胶囊减轻 LPS 诱导的大鼠免疫应激：疾病行为中的神经炎症和行为反应。
Curcumin-loaded lipid-core nanocapsules attenuates the immune challenge LPS-induced in rats: Neuroinflammatory and behavioral response in sickness behavior.
机构信息
Postgraduate Program in Pharmaceutical Sciences, Federal University of Pampa, Campus Uruguaiana, BR 472, Km 7, 97500-970 Uruguaiana, RS, Brazil.
Postgraduate Program in Biochemistry, Federal University of Pampa, UNIPAMPA, Uruguaiana, Brazil.
出版信息
J Neuroimmunol. 2020 Aug 15;345:577270. doi: 10.1016/j.jneuroim.2020.577270. Epub 2020 May 23.
The purpose of current study was to evaluate the effect of curcumin (CUR) loaded lipid-core nanocapsules (CUR-LNC) treatment on neuroinflammatory and behavioral alterations in a model of sickness behavior induced by lipopolysaccharide (LPS) in rats. Rats were treated with CUR-LNC and CUR daily for 14 days. After the last treatments, sickness behavior was induced with LPS. Sickness behavior LPS-induced was confirmed by behavioral tests, an increase in levels of proinflammatory cytokines, decrease in levels of IL-10, overexpression of IDO-1 and IDO-2. In conclusion, CUR-LNC treatment attenuated the neuroinflammatory and behavioral changes caused in sickness behavior model.
本研究旨在评估姜黄素（CUR）负载的脂芯纳米胶囊（CUR-LNC）治疗对脂多糖（LPS）诱导的大鼠病感行为模型中神经炎症和行为改变的影响。大鼠每日接受 CUR-LNC 和 CUR 治疗 14 天。最后一次治疗后，用 LPS 诱导病感行为。通过行为测试、促炎细胞因子水平升高、IL-10 水平降低、IDO-1 和 IDO-2 过表达，证实 LPS 诱导的病感行为。总之，CUR-LNC 治疗减轻了病感行为模型中引起的神经炎症和行为变化。
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