胃饥饿素对慢性心力衰竭组织中硫氧还蛋白表达的影响：系统评价与荟萃分析方案
Effect of grelin on TRX expression in chronic heart failure tissue: A protocol of systematic review and meta-analysis.
作者信息
Chen Zhe, Feng Yao, Zhang Ru-Bing, Li Xin, Xu Jian-Bo
机构信息
Department of Critical Medicine.
Department of Acupuncture and Moxibustion.
出版信息
Medicine (Baltimore). 2020 May 22;99(21):e20294. doi: 10.1097/MD.0000000000020294.
BACKGROUND
The aim of this study is to explore the effect of grelin on TRX expression (TRXE) in chronic heart failure tissue (CHFT).
METHODS
We will search electronic databases from inception to the March 1, 2020 in MEDLINE, EMBASE, Cochrane Library, CINAHL, PEDro, the Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. We will not apply any limitations to the language and publication status. Any randomized controlled trials (RCTs) that studied the effect of grelin on TRXE in CHFT will be included. Study quality will be checked by Cochrane risk of bias and evidence quality will be appraised by Grading of Recommendations Assessment Development and Evaluation. All extracted data will be analyzed by RevMan 5.3 Software.
RESULTS
This study will summarize the present RCTs to assess the effect of grelin on TRXE in CHFT.
CONCLUSION
The results of this study will provide conclusive evidence of the effect of grelin on TRXE in CHFT.
SYSTEMATIC REVIEW REGISTRATION
INPLASY202040078.
背景
本研究旨在探讨胃饥饿素对慢性心力衰竭组织（CHFT）中硫氧还蛋白表达（TRXE）的影响。
方法
我们将检索自数据库建立至2020年3月1日的电子数据库，包括MEDLINE、EMBASE、Cochrane图书馆、CINAHL、PEDro、补充与替代医学数据库、中国生物医学文献数据库和中国知网。我们将不对语言和出版状态施加任何限制。任何研究胃饥饿素对CHFT中TRXE影响的随机对照试验（RCT）都将被纳入。研究质量将通过Cochrane偏倚风险进行检查，证据质量将通过推荐分级评估、制定与评价进行评估。所有提取的数据将使用RevMan 5.3软件进行分析。
结果
本研究将总结目前的随机对照试验，以评估胃饥饿素对CHFT中TRXE的影响。
结论
本研究结果将为胃饥饿素对CHFT中TRXE的影响提供确凿证据。
系统评价注册
INPLASY202040078。
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