College of Clinical Medicine/College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Centre for Health, Activity, and Rehabilitation Research, School of Physiotherapy, University of Otago, Dunedin, Otago, New Zealand.
PLoS One. 2021 May 3;16(5):e0250685. doi: 10.1371/journal.pone.0250685. eCollection 2021.
Chinese herbal footbaths are an external therapy of traditional Chinese medicine that has been widely used to treat dysmenorrhea. This review aims to systematically evaluate its efficacy and safety for the treatment of dysmenorrhea.
Databases of PubMed, EMBASE, Cochrane Library, CIHAHL, Web of Science, Chinese National Knowledge Infrastructure(CNKI), Chinese Scientific Journals Database (VIP), Wanfang Database, China Biomedical Literature Database(CBM), and Chinese Biomedical Literature Service System (SinoMed) will be searched from the inception to September 30, 2020. The eligible randomized controlled trials (RCTs) will be identified and included. The primary outcomes include pain intensity measured by validated scales of visual analog scale, numeric rating scale, and response rate of symptom reduction. The secondary outcomes are scores on validated pain questionnaires, quality of life measured by SF-36 or other validated scales, and adverse events. Study selection, data extraction, and assessment of bias risk will be conducted by two reviewers independently. RevMan software (V.5.3.5) will be utilized to perform data synthesis. Subgroup and sensitivity analysis will be performed when necessary. The strength of the evidence will be evaluated with the Grading of Recommendations Assessment, Development and Evaluation System.
A high-quality synthesis of current evidence of Chinese herbal footbaths for patients with dysmenorrhea will be provided in this study.
This systematic review will provide evidence of whether Chinese herbal footbaths are an effective and safe intervention for the treatment of dysmenorrhea.
PROSPERO CRD42020188256.
中药足浴是一种中医外治法，已广泛用于治疗痛经。本综述旨在系统评价其治疗痛经的疗效和安全性。
检索 PubMed、EMBASE、Cochrane 图书馆、CIHAHL、Web of Science、中国知网(CNKI)、中文科技期刊数据库(VIP)、万方数据库、中国生物医学文献数据库(CBM)和中国生物医学文献服务系统(SinoMed)，检索时间为 2020 年 9 月 30 日。合格的随机对照试验(RCTs)将被确定并纳入。主要结局包括视觉模拟评分、数字评分量表和症状缓解反应率等验证量表测量的疼痛强度。次要结局为验证性疼痛问卷评分、SF-36 或其他验证性量表测量的生活质量以及不良反应。研究选择、数据提取和偏倚风险评估将由两名评审员独立进行。RevMan 软件(V.5.3.5)将用于进行数据合成。必要时进行亚组和敏感性分析。证据的强度将用推荐评估、制定和评估系统进行评估。
本研究将对中药足浴治疗痛经患者的现有证据进行高质量综合分析。
本系统评价将提供中药足浴是否是一种治疗痛经有效且安全的干预措施的证据。
PROSPERO CRD42020188256。
