Aiempanakit Kumpol, Apinantriyo Benjawan
Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University.
Hematology Unit, Medical Specialty Center, Bangkok Hospital Hat Yai, Bangkok Dusit Medical Services, Hat Yai, Songkhla, Thailand.
Medicine (Baltimore). 2020 May 22;99(21):e20389. doi: 10.1097/MD.0000000000020389.
Acute generalized exanthematous pustulosis (AGEP) is a severe pustular cutaneous adverse drug reaction. Sterile, non-follicular pustules overlying the erythematous skin characterize this reaction.
A 30-year-old Asian women presented with sterile, non-follicular lesions with pus-fluid levels on her back 2 days after taking clindamycin. Skin biopsy revealed a spongiotic change in the epidermis with a focal subcorneal pustule and perivascular eosinophil and lymphocyte infiltration.
Clindamycin-induced AGEP.
We discontinued clindamycin treatment and prescribed systemic corticosteroids.
The pustule stopped spreading within 1 day and the rash improved within 2 days.
AGEP is a pustular cutaneous adverse drug reaction that can appear with pus-fluid levels, clinically mimicking Sneddon-Wilkinson disease. The differentiation between both conditions is a history of drug use, characteristic skin lesions and histopathology.
急性泛发性脓疱性皮病（AGEP）是一种严重的脓疱性皮肤药物不良反应。这种反应的特征是在红斑皮肤上出现无菌性、非毛囊性脓疱。
一名30岁的亚洲女性在服用克林霉素2天后，背部出现无菌性、非毛囊性病变且有脓性液平面。皮肤活检显示表皮有海绵状改变，伴有局灶性角层下脓疱以及血管周围嗜酸性粒细胞和淋巴细胞浸润。
克林霉素诱发的AGEP。
我们停用了克林霉素治疗，并开具了全身性皮质类固醇药物。
脓疱在1天内停止扩散，皮疹在2天内好转。
AGEP是一种脓疱性皮肤药物不良反应，可出现脓性液平面，临床上类似于Sneddon-Wilkinson病。两种病症的鉴别在于用药史、特征性皮肤病变和组织病理学。
