Lin Wenxia, Yu Qianying, Qin Yuesi, Xiao Jianhua, Peng Li, Zhang Jie, He Jia, Xiang Haoyu, Xiao Min, Chen Mingling
Department of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine.
School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine.
Medicine (Baltimore). 2020 May 22;99(21):e20488. doi: 10.1097/MD.0000000000020488.
Psoriasis is a common, chronic, and recurrent skin inflammatory disease, with psoriasis vulgaris considered as the most prevalent type of psoriasis. Chinese herbal bath, a type of traditional Chinese medicine, is an external therapy widely used to treat psoriasis vulgaris in China, and it has achieved satisfactory clinical effects. However, there are few studies evaluating the safety and efficacy of Chinese herbal bath compared with other external therapies administered under similar conditions. The purpose of this study is to comprehensively evaluate the clinical safety and efficacy of Chinese herbal bath in the treatment of psoriasis vulgaris through a systematic evaluation of the literature, so as to provide a reference basis for future clinical applications.
PubMed, Embase, CENTRAL, the Web of Science, the China Biology Medicine Database (CBM), the China National Knowledge Database (CNKI), the Wan Fang Database, and the Chong Qing VIP Database will be searched to collect randomized controlled trials of Chinese herbal bath used to treat psoriasis vulgaris. The search time limits will be from the establishment of the database to December 2019. Two researchers will independently screen the studies, extract data, and evaluate the risk of bias of the studies. Meta-analysis will be carried out with the RevMan5.3 software. The mean difference will be used as the effect index for the measurement data, and the odds ratio will be used as the effect index for the enumeration data. The 95% confidence interval will be provided for each effect. Heterogeneity among the results of each study will be evaluated by the Chi-square test.
This study will comprehensively evaluate the clinical safety and efficacy of Chinese herbal bath in the treatment of psoriasis vulgaris, so as to provide a reference basis for future clinical applications.
This study will provide a theoretical basis for the standardized administration of Chinese herbal bath. OSF REGISTRATION NUMBER:: doi: 10.17605/OSF.IO/4HRPJ.
银屑病是一种常见的慢性复发性皮肤炎症性疾病，寻常型银屑病被认为是最常见的银屑病类型。中药药浴作为一种传统中医疗法，在中国是广泛用于治疗寻常型银屑病的一种外治疗法，且已取得了满意的临床疗效。然而，与在类似条件下使用的其他外治疗法相比，评估中药药浴安全性和疗效的研究较少。本研究的目的是通过对文献的系统评价，全面评估中药药浴治疗寻常型银屑病的临床安全性和疗效，以便为未来的临床应用提供参考依据。
检索PubMed、Embase、CENTRAL、Web of Science、中国生物医学数据库（CBM）、中国知网（CNKI）、万方数据库和重庆维普数据库，以收集用于治疗寻常型银屑病的中药药浴随机对照试验。检索时间范围为各数据库建库至2019年12月。两名研究人员将独立筛选研究、提取数据并评估研究的偏倚风险。使用RevMan5.3软件进行Meta分析。计量资料采用均数差值作为效应指标，计数资料采用比值比作为效应指标。为每个效应提供95%置信区间。采用卡方检验评估各研究结果之间的异质性。
本研究将全面评估中药药浴治疗寻常型银屑病的临床安全性和疗效，以便为未来的临床应用提供参考依据。
本研究将为中药药浴的规范化应用提供理论依据。OSF注册号：doi: 10.17605/OSF.IO/4HRPJ。
