血清血管内皮生长因子水平与寻常型银屑病的关联：一项系统评价与荟萃分析方案

The association of serum vascular endothelial growth factor levels and psoriasis vulgaris: A protocol for systematic review and meta-analysis.

作者信息

Gong Juan, Yang Hua, Qi Dongwei, Tang Xueyong

机构信息

Department of Dermatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.

出版信息

Medicine (Baltimore). 2020 Aug 14;99(33):e21565. doi: 10.1097/MD.0000000000021565.

DOI:10.1097/MD.0000000000021565

PMID:32872007

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7437804/

Abstract

BACKGROUND

In recent years, more and more attention has been paid to the role of skin microcirculation in the pathogenesis of psoriasis. The vascular network of the skin is mainly distributed in the dermis and the subcutaneous fat layer join. The microvessels are composed of terminal arterioles, arteriovenous capillaries, and postcapillary venules. Vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of psoriasis by promoting angiogenesis. The purpose of this study is to evaluate the relationship between serum VEGF and psoriasis vulgaris.

METHODS

Embase, CENTRAL, PubMed, China Biology Medicine Database, China National Knowledge Database, Wan Fang Database, and Chong Qing VIP Database will be searched to collect case-control studies and cohort studies and evaluate the relationship between serum VEGF and psoriasis vulgaris. The search time limits will be from the establishment of the database to December 2020. Two researchers will independently screen the studies, extract data, and evaluate the risk of bias of the studies. The Meta-analysis will be carried out with the RevMan5.3 software. The quality of all included studies will be evaluated by the Newcastle-Ottawa scale.

RESULTS

This study will evaluate the relationship between serum VEGF and the pathogenesis of psoriasis vulgaris.

CONCLUSION

This study will provide a theoretical basis for the pathogenesis of psoriasis vulgaris.

OSF REGISTRATION NUMBER

DOI 10.17605/OSF.IO/6DV8P.

摘要

背景

近年来，皮肤微循环在银屑病发病机制中的作用越来越受到关注。皮肤的血管网络主要分布在真皮层和皮下脂肪层交界处。微血管由终末小动脉、动静脉毛细血管和毛细血管后微静脉组成。血管内皮生长因子（VEGF）通过促进血管生成在银屑病发病机制中起重要作用。本研究的目的是评估血清VEGF与寻常型银屑病之间的关系。

方法

检索Embase、CENTRAL、PubMed、中国生物医学数据库、中国知网数据库、万方数据库和重庆维普数据库，收集病例对照研究和队列研究，评估血清VEGF与寻常型银屑病之间的关系。检索时间范围为各数据库建库至2020年12月。两名研究人员将独立筛选研究、提取数据并评估研究的偏倚风险。使用RevMan5.3软件进行Meta分析。所有纳入研究的质量将采用纽卡斯尔-渥太华量表进行评估。