Wang Quan, Zhang Yijun, Du Jingyu, Lin Xiangjin
Department of Orthopedics, The First Affiliated Hospital of Zhejiang University, Hangzhou City, China.
Medicine (Baltimore). 2020 May 29;99(22):e19995. doi: 10.1097/MD.0000000000019995.
Currently, there remains a paucity of literature about the efficiency of proximal adductor canal block (PACB) versus distal adductor canal block (DACB) for pain management after total knee arthroplasty (TKA). The purpose of this study is to perform a randomized controlled trial to compare the efficiency of PACB versus DACB for early postoperative pain treatment after TKA.
This study is a 2-arm, parallel-group, randomized controlled trial that is conducted at a single university hospital in China. Subjects presenting for unilateral TKA are randomized in a 1:1 ratio to either a PACB or DACB group. The primary outcome of this noninferiority study is opioid consumption within the first 24 hours following surgery. Secondary outcomes include quadriceps strength, pain scores, distance ambulated, and patient satisfaction. Continuous variables are compared using Student t test.
This clinical trial is expected to provide evidence of whether the PACB and DACB provide similar analgesia after TKA.
This study protocol was registered in Research Registry (researchregistry5440).
目前，关于全膝关节置换术（TKA）后近端收肌管阻滞（PACB）与远端收肌管阻滞（DACB）在疼痛管理方面的有效性的文献仍然很少。本研究的目的是进行一项随机对照试验，比较PACB与DACB在TKA术后早期疼痛治疗中的有效性。
本研究是一项双臂、平行组、随机对照试验，在中国的一家大学医院进行。接受单侧TKA的受试者按1:1的比例随机分为PACB组或DACB组。这项非劣效性研究的主要结局是术后24小时内的阿片类药物消耗量。次要结局包括股四头肌力量、疼痛评分、行走距离和患者满意度。连续变量采用Student t检验进行比较。
本临床试验有望提供证据，证明PACB和DACB在TKA后是否提供相似的镇痛效果。
本研究方案已在Research Registry（researchregistry5440）注册。
