Amitabha Medical Clinic and Healing Center, Santa Rosa, CA, USA.
Integr Cancer Ther. 2020 Jan-Dec;19:1534735420922615. doi: 10.1177/1534735420922615.
Long-term patient survival in cancer is affected by drug resistance. Honokiol (HNK) is a small-molecule polyphenol isolated from the bark and seed cones of . HNK has been shown to enhance the effects of chemotherapy and inhibit drug resistance in preclinical models. HNK was well tolerated in multiple animal models when administered orally, intravenously (IV), and via intraperitoneal route. However, there are limited human data on the use of HNK in general, and specifically via IV (HNK-IV) in cancer. We aim to assess the efficacy, safety, and tolerability of HNK-IV in patients with drug-resistant tumors. This is a case study of 2 cancer patients who utilized HNK-IV as part of their cancer treatment regimen. The initial infusion of HNK was 10 mg/kg body weight, and subsequent treatments were increased up to 50 mg/kg according to individual tolerance, over 2 weeks. Positive clinical response was achieved in both patients, including improved symptoms and quality of life. No serious adverse side effects occurred, and there were no adverse effects on laboratory parameters (complete blood count, kidney, and liver function). Transient sedation and minor nausea were noted and resolved postinfusion. This is the first report of HNK-IV in human patients. Given the positive clinical results, safety, and tolerability, the use of HNK-IV warrants further investigation regarding optimum formulation, and its use as adjunctive therapy in cancer patients.
癌症患者的长期生存受耐药性影响。和厚朴酚（HNK）是从小叶樟的树皮和球果中分离得到的一种小分子多酚。研究表明，HNK 能增强化疗效果，抑制临床前模型中的耐药性。HNK 经口服、静脉（IV）和腹腔途径给药时，在多种动物模型中均具有良好的耐受性。然而，关于 HNK 的一般用途，特别是 IV 途径（HNK-IV）在癌症中的应用，人类数据有限。我们旨在评估 HNK-IV 治疗耐药性肿瘤患者的疗效、安全性和耐受性。这是 2 例癌症患者使用 HNK-IV 作为其癌症治疗方案一部分的病例研究。初始输注剂量为 10mg/kg 体重，根据个体耐受性，在 2 周内增加至 50mg/kg。两名患者均取得了阳性临床反应，包括症状和生活质量改善。未发生严重不良副作用，实验室参数（全血细胞计数、肾功能和肝功能）无不良影响。输注后出现短暂镇静和轻微恶心，输注后缓解。这是 HNK-IV 在人类患者中的首次报告。鉴于其阳性的临床结果、安全性和耐受性，HNK-IV 的使用值得进一步研究，包括最佳制剂的研究及其作为癌症患者辅助治疗的应用。
