Wang Ce, Cai Zehao, Huang Yue, Liu Xinrui, Liu Xing, Chen Feng, Li Wenbin
Department of Neuro-Oncology, Cancer Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Human Brain and Tissue Bank, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Front Neurol. 2023 Jun 22;14:1172860. doi: 10.3389/fneur.2023.1172860. eCollection 2023.
Glioblastoma is the most common and aggressive primary tumor in the central nervous system. There is no standard of care for patients with recurrent GBM. Honokiol is a pleiotropic lignan and has the potential to be a potent and safe anticancer agent in human GBM when it is encapsulated by liposomes. We report an efficient and safe response to three phases of treatment with liposomal honokiol in a patient with recurrent glioblastoma.
胶质母细胞瘤是中枢神经系统中最常见且侵袭性最强的原发性肿瘤。复发性胶质母细胞瘤患者尚无标准治疗方案。厚朴酚是一种具有多种生物活性的木脂素，当被脂质体包裹时，有可能成为一种有效且安全的抗人胶质母细胞瘤药物。我们报告了一名复发性胶质母细胞瘤患者对脂质体包裹的厚朴酚三个阶段治疗的高效且安全的反应。
