Department of Laboratory Medicine, National University Hospital, Singapore 119074, Republic of Singapore.
National Public Health Laboratory, Singapore 169612, Republic of Singapore.
J Med Microbiol. 2013 Jul;62(Pt 7):1086-1088. doi: 10.1099/jmm.0.053363-0. Epub 2013 Apr 4.
In this study, we describe the characterization of an infrequently encountered class A carbapenemase, IMI-1, from a clinical Enterobacter cloacae isolate. The isolate had high levels of resistance to carbapenems but retained susceptibility to expanded-spectrum cephalosporins. The blaIMI-1 gene was chromosomally encoded. Detection of the IMI-1 producer highlights the diversity of carbapenemases in a local clinical setting.
在这项研究中,我们描述了一种罕见的 A 类碳青霉烯酶 IMI-1 的特征,该酶来自临床分离的阴沟肠杆菌。该分离株对碳青霉烯类药物具有高水平的耐药性,但对扩展谱头孢菌素仍保持敏感性。blaIMI-1 基因位于染色体上。IMI-1 产生菌的检测突出了本地临床环境中碳青霉烯酶的多样性。