Wernerman J, Sylvén C, von der Decken A, Jansson E, Böök K, Vinnars E
Department of Anaesthesiology and Intensive Care, Huddinge University Hospital, Sweden.
Cardiovasc Res. 1988 Aug;22(8):562-5. doi: 10.1093/cvr/22.8.562.
Protein synthesis as assessed by the concentration and size distribution of ribosomes was determined together with citrate synthase activity in papillary muscles obtained at open heart surgery from patients with mitral valve disease. The results were compared with corresponding data from the quadriceps femoris muscle of patients undergoing cholecystectomy. Citrate synthase activity was six times higher in papillary muscle than in skeletal muscle. The total ribosome concentration per mg DNA was similar in the two types of muscle. Compared with skeletal muscle, in papillary muscle polyribosomes constituted a higher proportion of the ribosomes (p less than 0.001), and there was a tendency towards larger polyribosome aggregates. It is proposed that the high concentration of polyribosomes in papillary muscle is related to the high oxidative capacity of that tissue.
通过核糖体的浓度和大小分布评估蛋白质合成，并与二尖瓣疾病患者心脏直视手术中获取的乳头肌中的柠檬酸合酶活性一起测定。将结果与胆囊切除术患者股四头肌的相应数据进行比较。乳头肌中的柠檬酸合酶活性比骨骼肌高六倍。每毫克DNA的总核糖体浓度在两种肌肉中相似。与骨骼肌相比，乳头肌中的多核糖体占核糖体的比例更高（p小于0.001），并且多核糖体聚集体有变大的趋势。有人提出，乳头肌中多核糖体的高浓度与该组织的高氧化能力有关。
