肱动脉血流介导的血管舒张功能与痴呆风险：心血管健康研究
Brachial Flow-mediated Dilation and Risk of Dementia: The Cardiovascular Health Study.
作者信息
Garg Parveen K, Tan Annabel X, Odden Michelle C, Gardin Julius M, Lopez Oscar L, Newman Anne B, Rawlings Andreea M, Mukamal Kenneth J
机构信息
Division of Cardiology, University of Southern California Keck School of Medicine, Los Angeles.
Department of Epidemiology and Population Health, Stanford University, Palo Alto, CA.
出版信息
Alzheimer Dis Assoc Disord. 2020 Jul-Sep;34(3):272-274. doi: 10.1097/WAD.0000000000000394.
INTRODUCTION
Brachial flow-mediated dilation (FMD) is a physiologic measure of endothelial function. We determined the prospective association of brachial FMD with incident dementia among older adults.
METHODS
We included 2777 Cardiovascular Health Study participants who underwent brachial FMD measurement. Incident dementia was ascertained by medication use, International Classification of Diseases-9 codes, requirement for a proxy, and death certificates and calibrated to gold-standard assessments performed in a subset of the cohort.
RESULTS
Mean participant age at time of brachial FMD measurement was 77.9 years. We identified 1650 incident dementia cases (median follow-up=10.5 y). After adjusting for age, race, sex, education, clinic site, and baseline arterial diameter, risk of dementia for participants in the highest quartile of percent brachial FMD did not differ from those in lowest quartile (hazard ratio=0.89, 95% confidence interval: 0.77, 1.03).
CONCLUSIONS
Brachial FMD, measured late in life, is not associated with an increased risk of incident dementia.
引言
肱动脉血流介导的血管舒张功能（FMD）是一种评估内皮功能的生理学指标。我们确定了老年人肱动脉FMD与新发痴呆症之间的前瞻性关联。
方法
我们纳入了2777名接受肱动脉FMD测量的心血管健康研究参与者。新发痴呆症通过药物使用、国际疾病分类第九版编码、代理人需求和死亡证明来确定，并与在队列亚组中进行的金标准评估进行校准。
结果
进行肱动脉FMD测量时参与者的平均年龄为77.9岁。我们确定了1650例新发痴呆症病例（中位随访时间=10.5年）。在调整年龄、种族、性别、教育程度、诊所地点和基线动脉直径后，肱动脉FMD百分比最高四分位数的参与者患痴呆症的风险与最低四分位数的参与者没有差异（风险比=0.89，95%置信区间：0.77，1.03）。
结论
在生命后期测量的肱动脉FMD与新发痴呆症风险增加无关。
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