Lee Kunsong, Choe Byung-Ho, Kang Ben, Kim Seung, Kim Jae Young, Shim Jung Ok, Lee Yoo Min, Lee Eun Hye, Jang Hyo-Jeong, Ryoo Eell, Yang Hye Ran
Department of Pediatrics, Dankook University College of Medicine, Cheonan, Korea.
Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Korea.
Pediatr Gastroenterol Hepatol Nutr. 2020 May;23(3):231-242. doi: 10.5223/pghn.2020.23.3.231. Epub 2020 May 8.
In East Asian countries, there are only a few epidemiologic studies of eosinophilic esophagitis (EoE) and no studies in children. We investigated the incidence and compared the clinical characteristics of EoE and eosinophilic gastroenteritis involving the esophagus (EGEIE) in Korean children.
A total of 910 children, who had symptoms of esophageal dysfunction, from 10 hospitals in Korea were included. EoE was diagnosed according to diagnostic guidelines and EGEIE was diagnosed when there were >15 eosinophils in the esophagus per high power field (HPF) and >20 eosinophils per HPF deposited in the stomach and duodenum with abnormal endoscopic findings.
Of the 910 subjects, 14 (1.5%) were diagnosed with EoE and 12 (1.3%) were diagnosed with EGEIE. Vomiting was the most common symptom in 57.1% and 66.7% of patients with EoE and EGEIE, respectively. Only diarrhea was significantly different between EoE and EGEIE (=0.033). In total, 61.5% of patients had allergic diseases. Exudates were the most common endoscopic findings in EoE and there were no esophageal strictures in both groups. The median age of patients with normal endoscopic findings was significantly younger at 3.2 years, compared to the median age of 11.1 years in those with abnormal endoscopic findings (=0.004).
The incidence of EoE in Korean children was lower than that of Western countries, while the incidence of EGEIE was similar to EoE. There were no clinical differences except for diarrhea and no differences in endoscopic findings between EoE and EGEIE.
在东亚国家，嗜酸性粒细胞性食管炎（EoE）的流行病学研究较少，且尚无针对儿童的研究。我们调查了韩国儿童中EoE和累及食管的嗜酸性粒细胞性胃肠炎（EGEIE）的发病率，并比较了两者的临床特征。
纳入了韩国10家医院共910例有食管功能障碍症状的儿童。根据诊断指南诊断EoE，当食管每高倍视野（HPF）嗜酸性粒细胞>15个，且胃和十二指肠每HPF嗜酸性粒细胞>20个，同时内镜检查结果异常时诊断为EGEIE。
910名受试者中，14例（1.5%）被诊断为EoE，12例（1.3%）被诊断为EGEIE。呕吐是EoE和EGEIE患者中最常见的症状，分别占57.1%和66.7%。EoE和EGEIE之间仅腹泻有显著差异（P=0.033）。共有61.5%的患者患有过敏性疾病。渗出物是EoE中最常见的内镜检查结果，两组均无食管狭窄。内镜检查结果正常的患者中位年龄显著更年轻，为3.2岁，而内镜检查结果异常的患者中位年龄为11.1岁（P=0.004）。
韩国儿童EoE的发病率低于西方国家，而EGEIE的发病率与EoE相似。除腹泻外，EoE和EGEIE在临床和内镜检查结果上无差异。
