Zdanowicz Katarzyna, Kucharska Magdalena, Sobaniec-Lotowska Maria Elzbieta, Lebensztejn Dariusz Marek, Daniluk Urszula
Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and Allergology, Medical University of Bialystok, 15-274 Bialystok, Poland.
Department of Medical Pathomorphology, Medical University of Bialystok, 15-274 Bialystok, Poland.
J Clin Med. 2020 Nov 28;9(12):3869. doi: 10.3390/jcm9123869.
An increase in the incidence of eosinophilic esophagitis worldwide is being observed in children. The aim of the study was to analyze the incidence, clinical manifestations, biochemical markers and endoscopic features of children with eosinophilic esophagitis in comparison to patients with non-eosinophilic esophagitis.
This single-center retrospective study included newly diagnosed children with eosinophilic (EoE) and non-eosinophilic (non-EoE) esophagitis based on endoscopic and histopathological results between January 2013 and December 2018.
Among 433 of enrolled children with esophagitis, 36 (8.31%) were diagnosed with EoE (median age of 10 years). Male predominance and an increased percentage of allergy cases in the EoE group were noticed. Dysphagia was the only symptom that significantly differentiated both groups ( = 0.006). Endoscopic findings with relevant relationships with EoE included linear fissuring, decreased vascular pattern, trachealization and whitish exudates. No significant difference in the prevalence of other reported diseases between groups was observed.
The results of EoE analysis in children from North-Eastern Poland did not differ from reports from other countries. The reported symptoms were not specific for EoE, and only dysphagia and some endoscopic lesions were helpful to differentiate children with EoE from non-EoE.
全球范围内，儿童嗜酸性粒细胞性食管炎的发病率正在上升。本研究旨在分析嗜酸性粒细胞性食管炎患儿与非嗜酸性粒细胞性食管炎患儿的发病率、临床表现、生化标志物及内镜特征，并进行对比。
这项单中心回顾性研究纳入了2013年1月至2018年12月期间根据内镜和组织病理学结果新诊断的嗜酸性粒细胞性（EoE）和非嗜酸性粒细胞性（非EoE）食管炎患儿。
在433名登记的食管炎患儿中，36名（8.31%）被诊断为EoE（中位年龄10岁）。EoE组中男性占优势且过敏病例百分比增加。吞咽困难是唯一能显著区分两组的症状（P = 0.006）。与EoE有相关关系的内镜表现包括线性裂隙、血管纹理减少、气管化和白色渗出物。两组间其他报告疾病的患病率无显著差异。
波兰东北部儿童EoE分析结果与其他国家的报告无差异。所报告的症状对EoE不具有特异性，只有吞咽困难和一些内镜下病变有助于区分EoE患儿与非EoE患儿。
