Koduru P, Chaganti R
Laboratory of Cancer Genetics and Cytogenetics, Memorial Sloan-Kettering Cancer Center, New York, NY.
Cytogenet Cell Genet. 1988;49(4):269-74. doi: 10.1159/000132675.
Analysis of the distribution of published chromosome breaks in cells with constitutional chromosome aberrations showed a nonrandom distribution of breaks among chromosomes and chromosome regions. A significant amount of breakage occurred at Giemsa-negative bands. In addition, chromosome sites associated with a number of fragile sites and cellular oncogene sites were affected nonrandomly. The data are consistent with the hypothesis that chromosome breakage occurs in somatic or germ cells as a result of recombinational errors involving actively transcribing chromatin regions or regions of unstable DNA sequence structure placed in proximity during interphase.
对具有先天性染色体畸变的细胞中已发表的染色体断裂分布进行分析，结果显示染色体和染色体区域之间的断裂分布并非随机。大量断裂发生在吉姆萨阴性带。此外，与多个脆性位点和细胞癌基因位点相关的染色体位点也受到非随机影响。这些数据与以下假设一致：染色体断裂发生在体细胞或生殖细胞中，是由于在间期涉及活跃转录染色质区域或不稳定DNA序列结构区域在邻近位置发生的重组错误所致。
