Department of Obstetrics, Second Hospital of Lanzhou University, Second Clinical Medical College of Lanzhou University, Lanzhou, China.
Department of Obstetrics and Gynecology, Third Hospital of Xian, Shaanxi Province, China.
Curr Drug Metab. 2020;21(5):352-356. doi: 10.2174/1389200221666200525152441.
Preeclampsia is a serious pregnancy-specific disease that affects about 5%-8% of pregnant women and is the main reason for the increase in maternal and perinatal mortality. Due to unknown etiology, preeclampsia is still the main cause of increased mortality in maternal and perinatal infants, which is mainly manifested by new hypertension after 20 weeks of pregnancy. As the pathogenesis has not been fully elucidated, early diagnosis and full treatment are lacking. Exosomes secreted from the placenta to the peripheral circulation may be involved in the pathogenesis of preeclampsia and can be detected from the plasma of pregnant women after 6 weeks of pregnancy. Related studies have shown that the levels of exosomes in preeclampsia have changed, and the protein and miRNA expression profiles are also different. Therefore, monitoring changes in plasma exosomes and expression profiles may provide new ideas and new perspectives for the prediction, diagnosis and treatment of preeclampsia.
子痫前期是一种严重的妊娠特有疾病，影响约 5%-8%的孕妇，是导致孕产妇和围产儿死亡率增加的主要原因。由于病因不明，子痫前期仍是孕产妇和围产儿死亡增加的主要原因，主要表现为妊娠 20 周后出现新的高血压。由于发病机制尚未完全阐明，早期诊断和充分治疗不足。胎盘分泌到外周循环的外泌体可能参与子痫前期的发病机制，可在妊娠 6 周后的孕妇血浆中检测到。相关研究表明，子痫前期中外泌体的水平发生了变化，蛋白质和 miRNA 表达谱也不同。因此，监测血浆外泌体和表达谱的变化可能为子痫前期的预测、诊断和治疗提供新的思路和新视角。
