MnO 纳米刺作为纳米佐剂和免疫原性细胞死亡药物，具有增强的抗肿瘤免疫和抗转移作用。
MnO Nanospikes as Nanoadjuvants and Immunogenic Cell Death Drugs with Enhanced Antitumor Immunity and Antimetastatic Effect.
机构信息
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
University of Science and Technology of China, Hefei, 230026, China.
出版信息
Angew Chem Int Ed Engl. 2020 Sep 14;59(38):16381-16384. doi: 10.1002/anie.202005111. Epub 2020 Jul 13.
Despite the widespread applications of manganese oxide nanomaterials (MONs) in biomedicine, the intrinsic immunogenicity of MONs is still unclear. MnO nanospikes (NSs) as tumor microenvironment (TME)-responsive nanoadjuvants and immunogenic cell death (ICD) drugs are proposed for cancer nanovaccine-based immunotherapy. MnO NSs with large mesoporous structures show ultrahigh loading efficiencies for ovalbumin and tumor cell fragment. The combination of ICD via chemodynamic therapy and ferroptosis inductions, as well as antigen stimulations, presents a better synergistic immunopotentiation action. Furthermore, the obtained nanovaccines achieve TME-responsive magnetic resonance/photoacoustic dual-mode imaging contrasts, while effectively inhibiting primary/distal tumor growth and tumor metastasis.
尽管氧化锰纳米材料（MONs）在生物医学中的应用广泛，但 MONs 的固有免疫原性仍不清楚。MnO 纳米刺（NSs）作为肿瘤微环境（TME）响应性纳米佐剂和免疫原性细胞死亡（ICD）药物，被提议用于基于癌症纳米疫苗的免疫治疗。具有大介孔结构的 MnO NSs 对卵清蛋白和肿瘤细胞碎片表现出超高的负载效率。通过化学动力学治疗和铁死亡诱导以及抗原刺激的 ICD 联合作用，呈现出更好的协同免疫增强作用。此外，所获得的纳米疫苗实现了 TME 响应性磁共振/光声双模成像对比，同时有效抑制了原发性/远端肿瘤生长和肿瘤转移。
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