Kihn-Alarcón Alba J, Alvarado-Muñoz Juan F, Orozco-Fuentes Loida I, Calgua-Guerra Erwin, Fuentes-de Falla Vicky, Velarde Angel
Research Department, Liga Nacional Contra el Cáncer & Instituto de Cancerología, Guatemala City, Guatemala.
Oncology Department, Hospital Roosevelt, Guatemala City, Guatemala.
JCO Glob Oncol. 2020 May;6:761-765. doi: 10.1200/JGO.19.00398.
Worldwide cervical and breast cancers are among the most commonly diagnosed cancers and are leading cause of cancer deaths among females in low- and middle-income countries. In Guatemala, breast and cervical cancers are the main cause of cancer-related deaths among women. Therefore, the aim of this study was to determine the years of potential life lost (YPLL) as an indicator of premature deaths as a result of breast and cervical cancers.
Data on the number of deaths as a result of breast and cervical cancers (International Classification of Diseases [10th revision] codes C50 and C53) between 2012 and 2016 and age composition by quinquennials were retrieved from the Health Information System of the Guatemalan Health Ministry. On the basis of each individual's age at death, YPLL was estimated for females between 20 and 70 years of age.
A total of 1,476 deaths related to breast and cervical cancers was reported over the study period. The trend in breast cancer mortality rate and YPLL did not change from 2012 to 2016. The cervical cancer mortality rate has decreased to 10 deaths per 1 million habitants ( = .046). There has been a reduction in YPLL because of cervical cancer, from 50.18 YPLL in 2012 to 29.19 YPLL by 2016, mainly in women between 30 and 34 years of age, in whom YPLL decreased from 600 to 112.50 ( = .046).
Cervical cancer screening has significantly reduced the mortality rate of this malignancy, and screening of breast cancer must include creating awareness of the disease and providing access to women at risk.
在全球范围内,宫颈癌和乳腺癌是最常被诊断出的癌症类型,也是低收入和中等收入国家女性癌症死亡的主要原因。在危地马拉,乳腺癌和宫颈癌是女性癌症相关死亡的主要原因。因此,本研究的目的是确定潜在寿命损失年数(YPLL),作为乳腺癌和宫颈癌导致过早死亡的一个指标。
从危地马拉卫生部的健康信息系统中检索2012年至2016年期间因乳腺癌和宫颈癌死亡的人数(国际疾病分类[第10版]编码C50和C53)以及每五年的年龄构成数据。根据每个个体的死亡年龄,估算20至70岁女性的潜在寿命损失年数。
在研究期间,共报告了1476例与乳腺癌和宫颈癌相关的死亡病例。2012年至2016年,乳腺癌死亡率和潜在寿命损失年数的趋势没有变化。宫颈癌死亡率已降至每100万居民中有10例死亡(P = 0.046)。宫颈癌导致的潜在寿命损失年数有所减少,从2012年的50.18年降至2016年的29.19年,主要是30至34岁的女性,其潜在寿命损失年数从600年降至112.50年(P = 0.046)。
宫颈癌筛查显著降低了这种恶性肿瘤的死亡率,乳腺癌筛查必须包括提高对该疾病的认识,并为有风险的女性提供筛查途径。