IRCCS Fondazione Don Carlo Gnocchi, Via A. Capecelatro, 66, 20148, Milan, Italy.
IRCCS Fondazione Don Carlo Gnocchi, Via A. Capecelatro, 66, 20148, Milan, Italy.
Neuropsychologia. 2020 Sep;146:107504. doi: 10.1016/j.neuropsychologia.2020.107504. Epub 2020 May 30.
We explored with Diffusion Tensor Imaging (DTI) technique whether the ability to select words among competitive alternatives during word production is related to the integrity of the left uncinate fasciculus (UF) in Parkinson's disease (PD). Nineteen PD patients (10 right-sided and 9 left-sided) and 17 matched healthy controls (HC) took part in the study. Participants were asked to derive nouns from verbs (reading from to read) or to generate verbs from nouns (to build from building). Noun and verb production, in this task, differ in the number of lexical entries among which the response is selected, as the noun must be selected from a larger number of alternatives compared to the verb, and thus is more demanding of processing resources. DTI evaluation was obtained for each subject. Fractional anisotropy (FA) and mean diffusivity (MD) maps were derived from DTI and median FA and MD values were computed within the left and right UF. Then, FA and MD of the left and right UF were correlated with noun and verb production. Both the left and right UF-FA correlated with the global (noun + verb) production and noun production in the whole PD group. In right-sided PD, correlations were found with the contralateral UF-FA; in left-sided PD the correlations emerged with both the left and right UF-FA. The most difficult task, noun production, significantly correlated with the right UF-FA in left-sided PD. The left UF is involved in word selection processes, and the right UF intervenes when the selection is particularly demanding of attentional resources.
我们使用弥散张量成像（DTI）技术探讨了在单词产生过程中从竞争选择中选择单词的能力是否与帕金森病（PD）患者左侧钩束（UF）的完整性有关。19 名 PD 患者（10 名右侧和 9 名左侧）和 17 名匹配的健康对照者（HC）参加了这项研究。参与者被要求从动词中派生名词（从 read 到 to read）或从名词中生成动词（从 building 到 to build）。在这个任务中，名词和动词的产生在从词汇表中选择反应的条目数方面有所不同，因为与动词相比，名词必须从更多的替代项中选择，因此需要更多的处理资源。对每个参与者都进行了 DTI 评估。从 DTI 中得出分数各向异性（FA）和平均扩散系数（MD）图，并计算左、右 UF 中的中位数 FA 和 MD 值。然后，将左、右 UF 的 FA 和 MD 值与名词和动词的产生相关联。左、右 UF 的 FA 均与整个 PD 组的全局（名词+动词）产生和名词产生相关。在右侧 PD 中，与对侧 UF-FA 相关；在左侧 PD 中，与左、右 UF-FA 均相关。最困难的任务，名词产生，与左侧 PD 中右侧 UF-FA 显著相关。左 UF 参与单词选择过程，而右 UF 在选择特别需要注意力资源时介入。
