Rosenthal Sandra J, Josephs Travis, Kovtun Oleg, McCarty Richard
Department of Chemistry, Vanderbilt University, Nashville, TN 37240, USA; Department of Pharmacology, Vanderbilt University, Nashville, TN 37240, USA; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, USA.
Interdisciplinary Program in Neuroscience for Undergraduates, Vanderbilt University, Nashville, TN 37240, USA.
Neurosci Biobehav Rev. 2020 Aug;115:199-219. doi: 10.1016/j.neubiorev.2020.05.017. Epub 2020 May 30.
Bipolar disorders have an onset in late adolescence or early adulthood and patients may experience alternating episodes of mania and depression, with euthymic periods interspersed between these extremes of mood. Clinical research studies have shown that bipolar disorder patients exhibit disruptions in circadian and seasonal rhythms, even when they are symptom free. In addition, some bipolar patients display pronounced seasonal patterns in occurrence of manic and depressive episodes, time of year for disease onset, and age of onset. Several groups have emphasized the impact of seasonal changes in sunlight intensity on bipolar disorder, especially in locations farther from the equator. In this paper, we examine rate of change of solar insolation during the spring and fall in locations that vary in their distance from the equator and propose that seasonal changes in sunlight intensity may be tracked by the suprachiasmatic nucleus and affect disease onset and progression in seasonally susceptible bipolar patients.
双相情感障碍在青春期晚期或成年早期发病，患者可能会经历躁狂和抑郁的交替发作，在这两种极端情绪之间穿插着心境正常期。临床研究表明，双相情感障碍患者即使在无症状时，其昼夜节律和季节节律也会出现紊乱。此外，一些双相情感障碍患者在躁狂和抑郁发作的发生、疾病发作的年份时间以及发病年龄方面表现出明显的季节性模式。几个研究小组强调了阳光强度的季节性变化对双相情感障碍的影响，尤其是在离赤道较远的地区。在本文中，我们研究了离赤道距离不同的地区在春季和秋季期间太阳辐射的变化率，并提出阳光强度的季节性变化可能由视交叉上核追踪，并影响季节性易感双相情感障碍患者的疾病发作和进展。
