Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Neurosci Lett. 2020 Aug 24;734:135098. doi: 10.1016/j.neulet.2020.135098. Epub 2020 May 30.
Post-stroke cognitive impairment (PSCI) is a severe complication of stroke. Predicting PSCI is difficult because some risk factors for stroke, such as blood glucose level and blood pressure, are affected by many other elements. Although recent studies have shown that high serum uric acid (UA) levels are associated with cognitive dysfunction and may be a risk factor for PSCI, its impact remains unclear. Accordingly, the present study aimed to explore the association between serum UA level and PSCI. In total, 274 patients who experienced acute cerebral infarction, confirmed between January 2016 and December 2018, were enrolled. Baseline data and biological indicators were recorded. According to the Montreal Cognitive Assessment (MoCA) scores, patients were divided into two groups: PSCI and non-PSCI. Logistic regression analysis was used to determine possible risk factors for PSCI. Results demonstrated that serum UA levels were significantly higher in the PSCI group than in the non-PSCI group. Multivariable logistic analysis revealed that age, years of education, and UA level were independent risk factors for PSCI. PSCI patients were subdivided according to serum UA level: high and low. Hypertension history and homocysteine (Hcy) levels differed significantly between the high and low UA level groups. Further analysis revealed that a history of hypertension and Hcy demonstrated a certain correlation (r = 0.163, 0.162; P < 0.05), suggesting that serum UA level was an independent risk factor for PSCI. These findings indicate that serum UA level was correlated with PSCI in post-stroke patients and is anticipated to be used in clinical practice to reduce the incidence of PSCI.
卒中后认知障碍（PSCI）是卒中的严重并发症。预测 PSCI 很困难，因为一些卒中的风险因素，如血糖水平和血压，受到许多其他因素的影响。尽管最近的研究表明，高血清尿酸（UA）水平与认知功能障碍有关，可能是 PSCI 的一个风险因素，但它的影响仍不清楚。因此，本研究旨在探讨血清 UA 水平与 PSCI 之间的关系。共纳入 274 例 2016 年 1 月至 2018 年 12 月确诊的急性脑梗死患者。记录基线数据和生物学指标。根据蒙特利尔认知评估（MoCA）评分，患者分为 PSCI 组和非 PSCI 组。采用 Logistic 回归分析确定 PSCI 的可能危险因素。结果表明，PSCI 组血清 UA 水平明显高于非 PSCI 组。多变量 Logistic 分析显示，年龄、受教育年限和 UA 水平是 PSCI 的独立危险因素。根据血清 UA 水平将 PSCI 患者进一步细分：高和低。高血压病史和同型半胱氨酸（Hcy）水平在高和低 UA 水平组之间有显著差异。进一步分析显示，高血压病史和 Hcy 呈一定相关性（r=0.163，0.162；P<0.05），提示血清 UA 水平是 PSCI 的独立危险因素。这些发现表明，血清 UA 水平与卒中后患者的 PSCI 相关，有望在临床实践中用于降低 PSCI 的发生率。
