血清同型半胱氨酸水平与脑卒中后患者癫痫发作和认知功能的相关性。
The Correlations Between Serum Hcy Level and Seizures and Cognitive Function in Patients After Stroke.
机构信息
105809Jinggangshan University, Ji'an, China.
Neurology Department, 105809Affiliated Hospital of Jinggangshan University, Ji'an, China.
出版信息
Am J Alzheimers Dis Other Demen. 2022 Jan-Dec;37:15333175221146738. doi: 10.1177/15333175221146738.
BACKGROUNDS
Post-stroke cognitive dysfunction (PSCI), a set of illnesses ranging from moderate cognitive impairment to dementia, which is one of the most prevalent consequences following a stroke. Homocysteine (Hcy) has been related to a number of neurological and systemic diseases. It's also a known risk factor for cardiovascular disease and systemic atherosclerosis (CVD). The link between Hcy and PSCI, on the other hand, is unknown.
METHODS
Our hospital evaluated 325 patients with acute cerebral infarction between January 1, 2018 and December 1, 2021. There are biological markers and baseline data available. Patients were divided into two groups based on the results of the Montreal Cognitive Assessment (MoCA). The researchers performed logistic regression analysis to find variables that may be linked to PSCI.
RESULTS
HCY levels were significantly higher in PSCI patients than in non-PSCI patients. Age, education, seizure manifestation, and income level were all shown to be independent risk variables for PSCI in a multivariate logistic analysis. Hcy levels in PSCI patients differed considerably between the high and low groups. The high and low Hcy levels groups had significantly varied hypertension histories and urine levels. Hcy levels in PSCI patients differed considerably between the high and low groups. The high and low Hcy levels groups had significantly varied hypertension histories and urine levels.
CONCLUSION
Serum Hcy levels have been linked to PSCI in post-stroke patients, and researchers believe that serum Hcy levels will diminish PSCI.
背景
脑卒中后认知功能障碍（PSCI）是一组从中度认知障碍到痴呆的疾病，是脑卒中后最常见的后果之一。同型半胱氨酸（Hcy）与许多神经和系统疾病有关。它也是心血管疾病和全身动脉粥样硬化（CVD）的已知危险因素。另一方面，Hcy 与 PSCI 之间的联系尚不清楚。
方法
我们医院评估了 2018 年 1 月 1 日至 2021 年 12 月 1 日期间 325 例急性脑梗死患者。有生物标志物和基线数据。根据蒙特利尔认知评估（MoCA）的结果，患者被分为两组。研究人员进行了逻辑回归分析，以寻找可能与 PSCI 相关的变量。
结果
PSCI 患者的 Hcy 水平明显高于非 PSCI 患者。在多变量逻辑分析中，年龄、教育、癫痫发作表现和收入水平均被证明是 PSCI 的独立危险因素。PSCI 患者的 Hcy 水平在高、低组之间差异显著。高、低 Hcy 水平组的高血压病史和尿水平差异显著。PSCI 患者的 Hcy 水平在高、低组之间差异显著。高、低 Hcy 水平组的高血压病史和尿水平差异显著。
结论
血清 Hcy 水平与脑卒中后患者的 PSCI 有关，研究人员认为血清 Hcy 水平会降低 PSCI。
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