Pourmehran Oveis, Cazzolato Benjamin, Tian Zhao, Arjomandi Maziar
School of Mechanical Engineering, the University of Adelaide, Adelaide, Australia.
School of Mechanical Engineering, the University of Adelaide, Adelaide, Australia.
Eur J Pharm Sci. 2020 Aug 1;151:105398. doi: 10.1016/j.ejps.2020.105398. Epub 2020 May 30.
This paper investigates the effect of aero-acoustic parameters on the efficiency of acoustically-driven drug delivery (ADD) to human maxillary sinus (MS). To be more specific, the effect of the frequency, amplitude at the acoustic excitation, and the inlet mean flow rate on the efficiency of ADD to the MS is studied. Direct computational aero-acoustics, using a validated computational fluid dynamics (CFD) model, has been utilised to carry out the parametric study. The transport pattern of the particles (drugs) in the presence of an external acoustic field has been investigated through the discrete phase model. Extensive computational simulations have revealed that the most important parameter in acoustically-driven drug delivery to the MS is the amplitude of the oscillation of the air plug in the ostium, which is largest when the combination of nasal cavity and MS is at resonance. Also, it has been found that the amplitude of the inlet acoustic wave has a direct correlation with the efficiency of the drug delivery to the MS. Moreover, the inlet mean airflow rate adversely affects the efficiency of the drug delivery to the MS. The results of this study suggest that applying an external acoustic field after distributing the drug particles with no mean flow results in a better drug delivery than in the presence of an inlet mean flow.
本文研究了气动声学参数对声驱动药物输送（ADD）至人上颌窦（MS）效率的影响。更具体地说，研究了频率、声激励幅度和入口平均流速对ADD至MS效率的影响。利用经过验证的计算流体动力学（CFD）模型，通过直接计算气动声学进行了参数研究。通过离散相模型研究了外部声场存在时颗粒（药物）的传输模式。大量的计算模拟表明，声驱动药物输送至MS时最重要的参数是窦口处气栓振荡的幅度，当鼻腔和MS的组合处于共振时该幅度最大。此外，还发现入口声波的幅度与药物输送至MS的效率直接相关。而且，入口平均气流速度对药物输送至MS的效率有不利影响。本研究结果表明，在无平均流的情况下分布药物颗粒后施加外部声场比存在入口平均流时能实现更好的药物输送。
