Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Wadsworth Center, New York State Department of Health, Albany, NY, 12201, USA.
Environ Res. 2020 Aug;187:109676. doi: 10.1016/j.envres.2020.109676. Epub 2020 May 16.
Human exposure to poly- and perfluoroalkyl substances (PFASs) is widespread and has received considerable attention in recent years due to their link with adverse health outcomes, including bone health. Nevertheless, no earlier studies have reported serum PFAS concentrations, and their association with incident osteoporosis in populations in Saudi Arabia. In this clinical case-control study, serum samples collected from 208 individuals (n = 100 cases and n = 108 controls) aged 40-89 years from Jeddah, Saudi Arabia, were analyzed for 17 PFASs. Unconditional logistic regression was used to calculate odds ratios (ORs) for association between serum PFAS concentrations and osteoporosis, stratified by gender, age, serum calcium and vitamin D, previous history of fractures and thyroid disorders. Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorobutanoic acid (PFBA), perfluorononanoic acid (PFNA), perfluorohexane sulfonic acid (PFHxS), perfluoro-n-pentanoic acid (PFPeA) and perfluoroundecanoic acid (PFUnDA) were detected in >80% of serum samples analyzed. PFOS (overall median concentration: 5.08 ng/mL), PFHxS (1.49 ng/mL), PFOA (1.33 ng/mL) and PFNA (0.55 ng/mL) accounted for 94% and 80% of the total serum PFASs concentrations in cases and controls, respectively. Serum PFOA, PFNA and PFUnDA concentrations increased with age in Saudi women. Results from the crude models showed that individuals in the 2nd, 3rd and 4th quartiles of serum PFAS concentrations had 2.3-96-fold increase in odds of diagnosis for osteoporosis compared with those in the 1st quartile (rank order: PFUnDA > PFOA > PFNA > PFOS > PFHxS). Our results suggest that exposure to PFOA, PFOS, PFNA, PFHxS and PFUnDA was associated with osteoporosis in this sample of adult Saudi population.
人体接触多氟和全氟烷基物质 (PFAS) 的现象非常普遍，近年来，由于这些物质与包括骨骼健康在内的不良健康结果有关，因此受到了相当大的关注。然而，此前并没有研究报告过沙特阿拉伯人群的血清 PFAS 浓度及其与骨质疏松症发病之间的关系。在这项临床病例对照研究中，分析了来自沙特吉达 208 名年龄在 40-89 岁的个体（n=100 例病例和 n=108 例对照）的血清样本，共检测了 17 种 PFAS。使用非条件逻辑回归计算了血清 PFAS 浓度与骨质疏松症之间的关联的比值比 (OR)，按性别、年龄、血清钙和维生素 D、既往骨折和甲状腺疾病史进行分层。在所分析的血清样本中，超过 80%检测到全氟辛酸 (PFOA)、全氟辛烷磺酸 (PFOS)、全氟丁酸 (PFBA)、全氟壬酸 (PFNA)、全氟己烷磺酸 (PFHxS)、全氟戊酸 (PFPeA) 和全氟十一烷酸 (PFUnDA)。PFOS(总体中位数浓度：5.08ng/mL)、PFHxS(1.49ng/mL)、PFOA(1.33ng/mL) 和 PFNA(0.55ng/mL) 分别占病例和对照组总血清 PFAS 浓度的 94%和 80%。沙特女性的血清 PFOA、PFNA 和 PFUnDA 浓度随年龄增长而增加。未校正模型的结果表明，与第一四分位组相比，第二、三和四分位组的个体患骨质疏松症的几率增加了 2.3-96 倍（顺位：PFUnDA>PFOA>PFNA>PFOS>PFHxS）。我们的结果表明，在该沙特成年人群样本中，接触 PFOA、PFOS、PFNA、PFHxS 和 PFUnDA 与骨质疏松症有关。
