Cancer Molecular Pathology, School of Medicine, Griffith University, Gold Coast, Queensland, Australia.
Cancer Molecular Pathology, School of Medicine, Griffith University, Gold Coast, Queensland, Australia; Department of Surgery, Logan Hospital, Metro South Health, Meadowbrook, Queensland, Australia.
Crit Rev Oncol Hematol. 2020 Aug;152:102989. doi: 10.1016/j.critrevonc.2020.102989. Epub 2020 May 22.
This study reviews the relevant epidemiological studies associating cutaneous melanoma and breast carcinomas and provides an overview of the possible genetic, biological and bias factors that underpin this relationship. Standardised incidence ratio (SIR) for primary cutaneous melanoma after breast carcinoma ranged from 1.16 to 5.13 and ranged from 1.03 to 4.10 for primary breast carcinoma after cutaneous melanoma. Epidemiological studies highlight age, gender and use of radiotherapy and chemotherapy as potential risk factors for second primary cancers (SPCs). Mutations in BRCA2, CDKN2A, CDK4 and BAP1 may partly underlie any SPC association. The impact of socio-cultural factors and surveillance bias may be attributed to the findings of SPC partially or entirely. In conclusion, this study has highlighted the association between breast carcinoma and melanoma and identified various factors for further research and the optimised management of patients with both cancers.
本研究回顾了与皮肤黑色素瘤和乳腺癌相关的相关流行病学研究，并概述了支持这种关系的可能的遗传、生物学和偏倚因素。乳腺癌后原发性皮肤黑色素瘤的标准化发病比（SIR）范围为 1.16 至 5.13，皮肤黑色素瘤后原发性乳腺癌的 SIR 范围为 1.03 至 4.10。流行病学研究强调年龄、性别以及放疗和化疗的使用是第二原发癌（SPC）的潜在危险因素。BRCA2、CDKN2A、CDK4 和 BAP1 的突变可能部分解释了 SPC 的相关性。社会文化因素和监测偏差的影响可能部分或全部归因于 SPC 的发现。总之，本研究强调了乳腺癌和黑色素瘤之间的关联，并确定了各种因素，以进一步研究和优化患有这两种癌症的患者的管理。
