HTA Committee, Azienda Ospedaliero Universitaria Policlinico "G. Rodolico-San Marco", 95123 Catania, Italy.
Registro Tumori Integrato, Azienda Ospedaliero Universitaria Policlinico "G. Rodolico-San Marco", 95123 Catania, Italy.
Int J Environ Res Public Health. 2022 Sep 26;19(19):12201. doi: 10.3390/ijerph191912201.
The number of cancer survivors continues to increase, thanks to advances in cancer diagnosis and treatment. Unfortunately, the incidence of a second primary cancer (SPC) is also increasing, but limited studies reporting incidence data are available regarding multiple cancers. This study presents our observations on multiple primary malignant cancers, the associations between sites, and the inherent sex differences.
We report the data, disaggregated by sex, concerning the SPCs that were recorded in the "Registro Tumori Integrato" (RTI) a population-based cancer registry in Sicily, Italy, as observed in the period from 2003 to 2017, in a total population of approximately 2,300,000. SPCs were divided into synchronous and metachronous cancers. , third edition (ICD-O-3), was used for topographical and morphological classifications. Multiple primary cancers with multi-organ primitiveness were selected from the database of the RTI by extracting patients with more than one diagnosis. SPCs had different histology or morphology from the particular cancer that was considered to be the index cancer case. Multicenter or multifocal cancers, or metastases, were excluded. The percentages of cancer by sex and topography, the average age of incidence, and a breakdown by age were computed.
Differences were observed between sexes in terms of incidence and site for SPCs. The most frequent SPC was skin cancer (20% of the SPCs observed). The associations among sites of multiple cancers are reported.
There are many gaps in our knowledge of sex differences in cancer. The study of multiple primary cancers could bring more likely opportunities for evaluation of the cancer burden and trends that can be used to identify new research areas by population health programs, as well as for clinical researchers.
由于癌症诊断和治疗的进步，癌症幸存者的数量不断增加。不幸的是，第二原发癌（SPC）的发病率也在增加，但关于多种癌症发病率数据的有限研究报告。本研究介绍了我们对多种原发性恶性肿瘤的观察结果，以及部位之间的关联和固有性别差异。
我们报告了 2003 年至 2017 年期间在意大利西西里岛基于人群的癌症登记处“Registro Tumori Integrato”（RTI）记录的 SPC 数据，该登记处约有 230 万人口，按性别细分。SPC 分为同步和异时性癌症。使用国际疾病分类肿瘤学第 3 版（ICD-O-3）进行解剖学和形态学分类。从 RTI 数据库中选择具有多器官原始性的多原发性癌症，通过提取具有多个诊断的患者来选择。SPC 与被认为是索引癌症病例的特定癌症具有不同的组织学或形态学。排除多中心或多灶性癌症或转移。计算了按性别和部位的癌症百分比、发病的平均年龄以及按年龄细分。
SPC 在性别和部位方面存在差异。最常见的 SPC 是皮肤癌（观察到的 SPC 的 20%）。报告了多种癌症部位之间的关联。
我们对癌症性别差异的认识存在许多差距。对多原发性癌症的研究可以为评估癌症负担和趋势提供更多机会，这些趋势可以通过人群健康计划用于识别新的研究领域，也可以为临床研究人员提供机会。
