Influence of Genotype and T3111C Interaction with Cardiovascular Risk Factors on the Progression to Alzheimer's Disease in Subjective Cognitive Decline and Mild Cognitive Impairment Patients.

BACKGROUND

Some genes could interact with cardiovascular risk factors in the development of Alzheimer's disease. We aimed to evaluate the interaction between ε4 status, T3111C and C111G polymorphisms with cardiovascular profile in Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI).

METHODS

We included 68 patients who underwent clinical evaluation; neuropsychological assessment; , and genotyping at baseline; and neuropsychological follow-up every 12-24 months for a mean of 13 years. We considered subjects who developed AD and non-converters.

RESULTS

T3111C was detected in 47% of cases, C111G in 19% of cases. ε4 carriers presented higher risk of heart disease; C-carriers were more frequently smokers than non C-carriers. During the follow-up, 17 patients progressed to AD. Age at baseline, ε 4 and dyslipidemia increased the risk of conversion to AD. ε4 carriers with history of dyslipidemia showed higher risk to convert to AD compared to ε4- groups and ε4+ without dyslipidemia patients. C-carriers with history of blood hypertension had a higher risk of conversion to AD.

CONCLUSIONS

and T3111C seem to interact with cardiovascular risk factors in SCD and MCI patients influencing the progression to AD.