Bessi Valentina, Balestrini Juri, Bagnoli Silvia, Mazzeo Salvatore, Giacomucci Giulia, Padiglioni Sonia, Piaceri Irene, Carraro Marco, Ferrari Camilla, Bracco Laura, Sorbi Sandro, Nacmias Benedetta
Department of Neuroscience, Psychology, Drug Research and Child Health-University of Florence-Viale Pieraccini 6, 50139 Florence, Italy.
IRCCS Fondazione Don Carlo Gnocchi, via di Scandicci 269, 50143 Florence, Italy.
J Pers Med. 2020 May 29;10(2):45. doi: 10.3390/jpm10020045.
Some genes could interact with cardiovascular risk factors in the development of Alzheimer's disease. We aimed to evaluate the interaction between ε4 status, T3111C and C111G polymorphisms with cardiovascular profile in Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI).
We included 68 patients who underwent clinical evaluation; neuropsychological assessment; , and genotyping at baseline; and neuropsychological follow-up every 12-24 months for a mean of 13 years. We considered subjects who developed AD and non-converters.
T3111C was detected in 47% of cases, C111G in 19% of cases. ε4 carriers presented higher risk of heart disease; C-carriers were more frequently smokers than non C-carriers. During the follow-up, 17 patients progressed to AD. Age at baseline, ε 4 and dyslipidemia increased the risk of conversion to AD. ε4 carriers with history of dyslipidemia showed higher risk to convert to AD compared to ε4- groups and ε4+ without dyslipidemia patients. C-carriers with history of blood hypertension had a higher risk of conversion to AD.
and T3111C seem to interact with cardiovascular risk factors in SCD and MCI patients influencing the progression to AD.
在阿尔茨海默病的发展过程中，一些基因可能与心血管危险因素相互作用。我们旨在评估ε4状态、T3111C和C111G多态性与主观认知下降（SCD）和轻度认知障碍（MCI）患者心血管状况之间的相互作用。
我们纳入了68例接受临床评估、神经心理学评估、基线基因分型，并且每12 - 24个月进行一次神经心理学随访，平均随访13年的患者。我们将发展为阿尔茨海默病的患者和未转化者纳入研究。
47%的病例检测到T3111C，19%的病例检测到C111G。ε4携带者患心脏病的风险更高；C携带者比非C携带者吸烟更频繁。在随访期间，17例患者进展为阿尔茨海默病。基线年龄、ε4和血脂异常增加了转化为阿尔茨海默病的风险。与ε4 -组和无血脂异常的ε4 +患者相比，有血脂异常病史的ε4携带者转化为阿尔茨海默病的风险更高。有高血压病史的C携带者转化为阿尔茨海默病的风险更高。
C111G和T3111C似乎与SCD和MCI患者的心血管危险因素相互作用，影响向阿尔茨海默病的进展。
