Petrik Milos, Pfister Joachim, Misslinger Matthias, Decristoforo Clemens, Haas Hubertus
Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 77900 Olomouc, Czech Republic.
Department of Nuclear Medicine, Medical University Innsbruck, 6020 Innsbruck, Austria.
J Fungi (Basel). 2020 May 29;6(2):73. doi: 10.3390/jof6020073.
Invasive fungal infections such as aspergillosis are life-threatening diseases mainly affecting immuno-compromised patients. The diagnosis of fungal infections is difficult, lacking specificity and sensitivity. This review covers findings on the preclinical use of siderophores for the molecular imaging of infections. Siderophores are low molecular mass chelators produced by bacteria and fungi to scavenge the essential metal iron. Replacing iron in siderophores by radionuclides such as gallium-68 allowed the targeted imaging of infection by positron emission tomography (PET). The proof of principle was the imaging of pulmonary infection using [Ga]Ga-triacetylfusarinine C. Recently, this approach was expanded to imaging of bacterial infections, i.e., with Moreover, the conjugation of siderophores and fluorescent dyes enabled the generation of hybrid imaging compounds, allowing the combination of PET and optical imaging. Nevertheless, the high potential of these imaging probes still awaits translation into clinics.
侵袭性真菌感染，如曲霉病，是主要影响免疫功能低下患者的危及生命的疾病。真菌感染的诊断困难，缺乏特异性和敏感性。本综述涵盖了关于铁载体在感染分子成像临床前应用的研究结果。铁载体是细菌和真菌产生的低分子量螯合剂，用于 scavenge 必需的金属铁。用放射性核素如镓 - 68 取代铁载体中的铁，可通过正电子发射断层扫描（PET）对感染进行靶向成像。原理验证是使用[Ga]Ga - 三乙酰基富沙里宁 C 对肺部感染进行成像。最近，这种方法扩展到了细菌感染的成像，即使用 此外，铁载体与荧光染料的共轭能够生成混合成像化合物，实现 PET 和光学成像的结合。然而，这些成像探针的高潜力仍有待转化为临床应用。 （注：原文中“scavenge”这个词可能有误，推测是“scavenge for”，但按要求未修改，“scavenge”常见释义为“清除、 scavenge for为‘搜寻、 scavenge for寻找’”，这里结合语境，猜测作者想表达的是“寻找必需的金属铁”。）
