Oprea Madalina, Voicu Stefan Ioan
National Institute for Research and Development in Chemistry and Petrochemistry ICECHIM, Splaiul Independentei 202, 060021 Bucharest, Romania.
Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Gheorghe Polizu 1-7, 011061 Bucharest, Romania.
Materials (Basel). 2020 May 29;13(11):2481. doi: 10.3390/ma13112481.
The development of novel polymeric composites based on cellulose derivatives and hydroxyapatite represents a fascinating and challenging research topic in membranes science and technology. Cellulose-based materials are a viable alternative to synthetic polymers due to their favorable physico-chemical and biological characteristics. They are also an appropriate organic matrix for the incorporation of hydroxyapatite particles, inter and intramolecular hydrogen bonds, as well as electrostatic interactions being formed between the functional groups on the polymeric chains surface and the inorganic filler. The current review presents an overview on the main application fields of cellulose derivatives/hydroxyapatite composite membranes. Considering the versatility of hydroxyapatite particles, the hybrid materials offer favorable prospects for applications in water purification, tissue engineering, drug delivery, and hemodialysis. The preparation technique and the chemical composition have a big influence on the final membrane properties. The well-established membrane fabrication methods such as phase inversion, electrospinning, or gradual electrostatic assembly are discussed, together with the various strategies employed to obtain a homogenous dispersion of the inorganic particles in the polymeric matrix. Finally, the main conclusions and the future directions regarding the preparation and applications of cellulose derivatives/hydroxyapatite composite membranes are presented.
基于纤维素衍生物和羟基磷灰石的新型聚合物复合材料的开发是膜科学与技术中一个引人入胜且具有挑战性的研究课题。基于纤维素的材料因其良好的物理化学和生物学特性，是合成聚合物的可行替代品。它们也是用于掺入羟基磷灰石颗粒的合适有机基质，聚合物链表面的官能团与无机填料之间会形成分子间和分子内氢键以及静电相互作用。本综述概述了纤维素衍生物/羟基磷灰石复合膜的主要应用领域。考虑到羟基磷灰石颗粒的多功能性，这种杂化材料在水净化、组织工程、药物递送和血液透析等应用中具有良好的前景。制备技术和化学成分对最终膜性能有很大影响。本文讨论了诸如相转化、静电纺丝或逐步静电组装等成熟的膜制备方法，以及用于使无机颗粒在聚合物基质中均匀分散的各种策略。最后，给出了关于纤维素衍生物/羟基磷灰石复合膜制备和应用的主要结论及未来方向。
