Apollo Proton Cancer Centre, Chennai, India.
Radiat Oncol. 2020 Jun 1;15(1):138. doi: 10.1186/s13014-020-01538-y.
Developments in the field of proton beam therapy (PBT) have recently crossed the tipping point wherein the modality is now more versatile than ever before, with possibilities and likely indications expanding rapidly.However the pace of evidence generation lags behind the developments in the field.Generating quality evidence has its own set of challenges owing to complexities of conducting randomized controlled trials, which are the hallmark of level 1 evidence generation.Here we discuss various challenges to clinical evidence generation in PBT and have suggested certain solutions including collaborative approaches and alternative study designs to mitigate these challenges.
质子束治疗（PBT）领域的发展最近已经达到了一个转折点，该治疗方式现在比以往任何时候都更加多样化，可能性和可能的适应症迅速扩大。然而，证据生成的速度落后于该领域的发展。由于进行随机对照试验的复杂性，生成高质量证据本身也存在一系列挑战，而随机对照试验是一级证据生成的标志。在这里，我们讨论了 PBT 临床证据生成的各种挑战，并提出了一些解决方案，包括合作方法和替代研究设计，以减轻这些挑战。
