School of Materials Science & Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
School of Materials Science & Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China; School of Advanced Vocational Education, Shanghai University of Engineering Science, Shanghai 200437, China.
Mater Sci Eng C Mater Biol Appl. 2020 Aug;113:110988. doi: 10.1016/j.msec.2020.110988. Epub 2020 Apr 21.
Complex nanostructures are increasingly becoming important in the development of novel functional nanomaterials. Nano drug depots, characterized by core-shell structures with core drug reservoirs, are drawing increasing attention because of its potential applications in furnishing drug-sustained release profiles. In the present study, two kinds of nano drug depots, one containing a crystal drug reservoir and the other having a medicated composite drug reservoir, were prepared through modified triaxial electrospinning. Their drug-sustained release performances were compared in terms of initial burst release, middle linear release, and the late tailing off release. Although both depots had a linear morphology, clear core-shell nanostructures and the same cellulose acetate shell layer, they provided considerably different tailing off release performances, and thus different sustained release profiles. The composite-based drug depots showed a smaller tailing off drug amount of 2.2%, a shorter time period of 12 h, and a better zero-order controlled release kinetics in general than the crystal-based drug depots, whose tailing off amount was 9.3% over a time period of 36 h. The mechanism was proposed, which had a close relationship with the state of drug in the core reservoir. The present protocols open a new way for producing medicated structural nanomaterials.
复杂的纳米结构在新型功能纳米材料的发展中变得越来越重要。纳米药物库具有核-壳结构，其中包含药物储存核心，由于其在提供药物持续释放特性方面的潜在应用，因此受到越来越多的关注。在本研究中，通过改进的三轴静电纺丝法制备了两种纳米药物库，一种含有晶体药物储存库，另一种具有药物复合药物储存库。从初始突释、中期线性释放和后期尾端释放三个方面比较了它们的药物持续释放性能。尽管两种药物库都具有线性形态、明显的核壳纳米结构和相同的醋酸纤维素壳层，但它们提供了相当不同的尾端释放性能，从而提供了不同的持续释放特性。基于复合材料的药物库的尾端药物释放量较小，为 2.2%，时间较短，为 12 小时，且通常具有更好的零级控制释放动力学，而基于晶体的药物库的尾端药物释放量为 9.3%，时间为 36 小时。提出了一种与核心储库中药物状态密切相关的机制。本方案为生产药物结构纳米材料开辟了新途径。
