College of Chemistry & Chemical Engineering, Wuhan Textile University, Wuhan 430200, China.
School of Materials Science & Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
Int J Biol Macromol. 2020 Jun 1;152:68-76. doi: 10.1016/j.ijbiomac.2020.02.239. Epub 2020 Feb 22.
New strategies based on advanced technologies are highly desired for expanding the applications of biological macromolecules in the applied scientific fields. In the present study, a new kind of core-shell nano depots were designed, in which the shell section was a drug-polymer composite and the core section was a drug reservoir. With ethyl cellulose and ketoprofen as a filament-forming polymeric matrix and a model drug, respectively, a triaxial electrospinning apparatus was developed to conduct both coaxial and triaxial processes, by which monolithic nanofibers F1 and core-shell nano depots F2 were successfully prepared. Although both of them had the same double components, their different nanostructures generated considerable differences in providing drug sustained release profiles. The core-shell nanofiber depots F2 were able to provide a better zero-order drug release profile: no initial burst release, smooth sustained release effect, and smaller tailing-off release for a nice zero-order drug release kinetics. The release percentage (Q) can be linearly manipulated through the release time (t) according to the equation Q = 9.40 + 4.74 t (R = 0.9936), providing opportunity for precise administration. The developed strategy and advanced electrospinning technique exhibit a new way for constructing process-structure-performance relationships at nano scale and for expanding the potential applications of biological macromolecules in the applied fields.
为了拓展生物大分子在应用科学领域的应用，人们迫切需要基于先进技术的新策略。在本研究中，设计了一种新型的核壳纳米储库，其中壳层为药物-聚合物复合材料，核层为药物储库。以乙基纤维素和酮洛芬分别作为成纤聚合物基质和模型药物，开发了三轴静电纺丝装置，进行同轴和三轴工艺，成功制备了单根纳米纤维 F1 和核壳纳米储库 F2。尽管它们具有相同的双组分，但不同的纳米结构在提供药物持续释放曲线方面产生了显著差异。核壳纳米纤维储库 F2 能够提供更好的零级药物释放曲线：无初始突释，平稳持续释放效果，较小的尾部释放，具有良好的零级药物释放动力学。释放百分比（Q）可以根据方程 Q=9.40+4.74t（R=0.9936）通过释放时间（t）进行线性调节，为精确给药提供了机会。所开发的策略和先进的静电纺丝技术为在纳米尺度上构建工艺-结构-性能关系以及拓展生物大分子在应用领域的潜在应用提供了新途径。
