急性淋巴细胞白血病睾丸照射后睾丸间质细胞功能不全

Leydig cell insufficiency after testicular irradiation for acute lymphoblastic leukemia.

作者信息

Brauner R, Caltabiano P, Rappaport R, Leverger G, Schaison G

机构信息

Unité d'Endocrinologie Pédiatrique, INSERM U. 30, Hôpital des Enfants Malades, Paris, France.

出版信息

Horm Res. 1988;30(2-3):111-4. doi: 10.1159/000181040.

DOI:10.1159/000181040

PMID:3248774

Abstract

Leydig cell function in 21 boys with acute lymphoblastic leukemia who had been treated by bilateral direct testicular irradiation (12 X 2 Gy) at 8.4 +/- 0.7 years, was evaluated 3.8 +/- 0.4 years after irradiation. At the time of irradiation all were prepubertal and at evaluation 12 were prepubertal and 9 pubertal. Leydig cell insufficiency, indicated by a low plasma testosterone response to chorionic gonadotrophin and/or an increase in basal level of plasma luteinizing hormone, was observed in 19/21 patients. The children who were the youngest at testicular irradiation were more vulnerable. Spontaneous virilization occurred in 3 of the older children and resulted from compensated Leydig cell dysfunction.

摘要

对21名急性淋巴细胞白血病男孩的睾丸间质细胞功能进行了评估，这些男孩在8.4±0.7岁时接受了双侧直接睾丸照射（12次，每次2 Gy），在照射后3.8±0.4年进行评估。照射时所有患儿均未进入青春期，评估时12名未进入青春期，9名已进入青春期。在21名患者中有19名观察到睾丸间质细胞功能不全，表现为血浆睾酮对绒毛膜促性腺激素反应低下和/或血浆黄体生成素基础水平升高。睾丸照射时年龄最小的儿童更容易受到影响。3名年龄较大的儿童出现了自发性男性化，这是由代偿性睾丸间质细胞功能障碍引起的。