睾丸照射对青春期前急性淋巴细胞白血病男孩睾丸间质细胞功能的影响。
The effect of testicular irradiation on Leydig cell function in prepubertal boys with acute lymphoblastic leukaemia.
作者信息
Leiper A D, Grant D B, Chessells J M
出版信息
Arch Dis Child. 1983 Nov;58(11):906-10. doi: 10.1136/adc.58.11.906.
Testicular function was investigated by the luteinising hormone releasing hormone (LHRH) test and a three day human chorionic gonadotrophin (HCG) test in 11 prepubertal boys with acute lymphoblastic leukaemia (ALL) who had received 2400 rads of fractionated radiation to their testes after relapse at this site. The results were compared with an unirradiated control group. Basal and peak testosterone values after 1000 units of HCG were significantly lower in the irradiated patients than in the control group. Peak follicle stimulating hormone (FSH) values after 100 micrograms LHRH were significantly higher in irradiated boys, but there was no difference in either basal FSH or basal and peak luteinising hormone values. The findings suggest that the ability of the Leydig cell to produce testosterone--as detected by the HCG test--is appreciably reduced after irradiation and that tubular dysfunction in prepubertal boys may sometimes be predicted by a raised FSH response.
对11名青春期前患有急性淋巴细胞白血病（ALL）的男孩进行了研究，这些男孩在睾丸复发后接受了2400拉德分次照射，通过促黄体生成素释放激素（LHRH）试验和三天人绒毛膜促性腺激素（HCG）试验来调查睾丸功能。将结果与未受照射的对照组进行比较。照射患者在注射1000单位HCG后的基础睾酮值和峰值睾酮值显著低于对照组。照射男孩在注射100微克LHRH后的促卵泡生成素（FSH）峰值显著高于对照组，但基础FSH值以及基础和峰值促黄体生成素值均无差异。研究结果表明，通过HCG试验检测，照射后睾丸间质细胞产生睾酮的能力明显降低，青春期前男孩的肾小管功能障碍有时可通过FSH反应升高来预测。
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