Second Clinical Medical College, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
First Clinical Medical College, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Aging Clin Exp Res. 2021 May;33(5):1175-1185. doi: 10.1007/s40520-020-01605-0. Epub 2020 Jun 1.
Mild cognitive impairment (MCI) is a cognitive state falling between normal aging and dementia. The relation between alcohol intake and risk of MCI as well as progression to dementia in people with MCI (PDM) remained unclear.
To synthesize available evidence and clarify the relation between alcohol intake and risk of MCI as well as PDM.
We searched electronic databases consisting of PubMed, EMBASE, Cochrane Library, and China Biology Medicine disc (CBM) from inception to October 1, 2019. Prospective studies reporting at least three levels of alcohol exposure were included. Categorical meta-analysis was used for quantitative synthesis of the relation between light, moderate and heavy alcohol intake with risk of MCI and PDM. Restricted cubic spline and fixed-effects dose-response models were used for dose-response analysis.
Six cohort studies including 4244 individuals were finally included. We observed an unstable linear relation between alcohol intake (drinks/week) and risk of MCI (P linear = 0.0396). It suggested that a one-drink increment per week of alcohol intake was associated with an increased risk of 3.8% for MCI (RR, 1.038; 95% CI 1.002-1.075). Heavy alcohol intake (> 14 drinks/week) was associated with higher risk of PDM (RR = 1.76; 95% CI 1.10-2.82). And we found a nonlinear relation between alcohol intake and risk of PDM. Drinking more than 16 drinks/week (P nonlinear = 0.0038, HR = 1.42; 95% CI 1.00-2.02), or 27.5 g/day (P nonlinear = 0.0047, HR = 1.46; 95% CI 1.00-2.11) would elevate the risk of PDM.
There was a nonlinear dose-response relation between alcohol intake and risk of PDM. Excessive alcohol intake would elevate the risk of PDM.
轻度认知障碍（MCI）是一种介于正常衰老和痴呆之间的认知状态。饮酒与 MCI 患者发生 MCI（PDM）的风险以及向痴呆进展的关系仍不清楚。
综合现有证据，阐明饮酒与 MCI 风险以及 PDM 的关系。
我们检索了包含 PubMed、EMBASE、Cochrane 图书馆和中国生物医学文献数据库（CBM）的电子数据库，检索时间为从建库至 2019 年 10 月 1 日。纳入至少报告 3 个饮酒水平的前瞻性研究。采用分类荟萃分析定量综合轻、中、重度饮酒与 MCI 和 PDM 风险之间的关系。采用限制立方样条和固定效应剂量-反应模型进行剂量-反应分析。
最终纳入 6 项队列研究，共 4244 人。我们观察到饮酒量（每周饮酒量）与 MCI 风险之间呈不稳定的线性关系（P 线性=0.0396）。这表明每周增加 1 份酒精饮料与 MCI 风险增加 3.8%相关（RR，1.038；95%CI，1.002-1.075）。重度饮酒（>14 份/周）与 PDM 风险较高相关（RR=1.76；95%CI，1.10-2.82）。并且我们发现饮酒与 PDM 风险之间存在非线性关系。每周饮酒超过 16 份（P 非线性=0.0038，HR=1.42；95%CI，1.00-2.02）或 27.5 g/天（P 非线性=0.0047，HR=1.46；95%CI，1.00-2.11）会增加 PDM 的风险。
饮酒与 PDM 风险之间存在非线性剂量-反应关系。过量饮酒会增加 PDM 的风险。
