Lao Yongfeng, Li Xiaolong, He Lijuan, Guan Xin, Li Rongxin, Wang Yanan, Li Yanyou, Wang Yunchang, Li Xu, Liu Shuai, Dong Zhilong
Second Clinical Medical College, Lanzhou University, Lanzhou, China.
Department of Urology, Lanzhou University Second Hospital, Lanzhou, China.
Front Oncol. 2021 Sep 15;11:696676. doi: 10.3389/fonc.2021.696676. eCollection 2021.
Controversial results of the association between alcohol consumption and risk of bladder cancer were reported by the previous meta-analyses.
To quantitatively investigate the association between alcohol consumption and risk of bladder cancer based on prospective cohort studies, and explore whether there is potential dose-response relation.
PubMed, EMBASE, the Cochrane Library databases, China Biology Medicine disc (CBM), and Chinese National Knowledge Infrastructure (CNKI) were searched for relevant studies. Categorical meta-analysis was performed for risk estimates of any alcohol consumers versus non-drinkers as well as different drinking degrees (light, moderate, and heavy) versus none. And two-stage generalized least-squares regression and restricted cubic spline, as well as fixed-effects dose-response models, were used for linear and nonlinear dose-response relation exploration.
9 prospective cohort studies including 1,971,396 individuals were finally included. We did not observe a significant association between alcohol intake and the risk of bladder cancer in the entire population. Linear association was detected in those who consumed alcohol from liquor or spirits (P =0.02). One drink increment each day of alcohol could elevate the risk of bladder cancer by 9% (RR=1.09; 95%CI: 1.01-1.17). Alcohol was a risk factor of bladder cancer for male drinkers (RR=1.23; 95%CI: 1.13-1.35; I=3.7%), while none linear or nonlinear relation was found.
No significant association between alcohol consumption and bladder cancer risk was found in the entire population, but there was a linear dose-response relation in those who consume alcohol from liquor or spirits. Alcohol may elevate the risk of bladder cancer in males in a dose-independent way.
https://www.crd.york.ac.uk/prospero/, PROSPERO (CRD42020216195).
先前的荟萃分析报告了饮酒与膀胱癌风险之间存在有争议的结果。
基于前瞻性队列研究定量调查饮酒与膀胱癌风险之间的关联，并探讨是否存在潜在的剂量反应关系。
检索了PubMed、EMBASE、Cochrane图书馆数据库、中国生物医学光盘数据库（CBM）和中国知网（CNKI）以查找相关研究。对任何饮酒者与不饮酒者以及不同饮酒程度（轻度、中度和重度）与不饮酒者的风险估计进行分类荟萃分析。并使用两阶段广义最小二乘回归和受限立方样条以及固定效应剂量反应模型来探索线性和非线性剂量反应关系。
最终纳入了9项前瞻性队列研究，共1971396人。我们在整个人口中未观察到饮酒与膀胱癌风险之间存在显著关联。在饮用白酒或烈酒的人群中检测到线性关联（P = 0.02）。每天饮酒量每增加一杯可使膀胱癌风险升高9%（RR = 1.09；95%CI：1.01 - 1.17）。酒精是男性饮酒者患膀胱癌的危险因素（RR = 1.23；95%CI：1.13 - 1.35；I² = 3.7%），但未发现线性或非线性关系。
在整个人口中未发现饮酒与膀胱癌风险之间存在显著关联，但在饮用白酒或烈酒的人群中存在线性剂量反应关系。酒精可能以剂量无关的方式增加男性患膀胱癌的风险。
https://www.crd.york.ac.uk/prospero/，PROSPERO（CRD42020216195）。
