Liu Shurong, Li Bin, Liang Qiaoxia, Liu Anrui, Qu Lianghu, Yang Jianhua
MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Department of Interventional Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Wiley Interdiscip Rev RNA. 2020 Nov;11(6):e1601. doi: 10.1002/wrna.1601. Epub 2020 Jun 2.
Almost all RNAs need to interact with proteins to fully exert their functions, and proteins also bind to RNAs to act as regulators. It has now become clear that RNA-protein interactions play important roles in many biological processes among organisms. Despite the great progress that has been made in the field, there is still no precise classification system for RNA-protein interactions, which makes it challenging to further decipher the functions and mechanisms of these interactions. In this review, we propose four different categories of RNA-protein interactions according to their basic characteristics: RNA motif-dependent RNA-protein interactions, RNA structure-dependent RNA-protein interactions, RNA modification-dependent RNA-protein interactions, and RNA guide-based RNA-protein interactions. Moreover, the integration of different types of RNA-protein interactions and the regulatory factors implicated in these interactions are discussed. Furthermore, we emphasize the functional diversity of these four types of interactions in biological processes and disease development and assess emerging trends in this exciting research field. This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications RNA Interactions with Proteins and Other Molecules > Protein-RNA Recognition RNA Processing > RNA Editing and Modification.
几乎所有的RNA都需要与蛋白质相互作用才能充分发挥其功能，而蛋白质也会与RNA结合以充当调节因子。现在已经清楚，RNA-蛋白质相互作用在生物体的许多生物学过程中发挥着重要作用。尽管该领域已经取得了巨大进展，但对于RNA-蛋白质相互作用仍没有精确的分类系统，这使得进一步解读这些相互作用的功能和机制具有挑战性。在本综述中，我们根据其基本特征提出了四类不同的RNA-蛋白质相互作用：RNA基序依赖性RNA-蛋白质相互作用、RNA结构依赖性RNA-蛋白质相互作用、RNA修饰依赖性RNA-蛋白质相互作用以及基于RNA引导的RNA-蛋白质相互作用。此外，还讨论了不同类型RNA-蛋白质相互作用的整合以及涉及这些相互作用的调节因子。此外，我们强调了这四种相互作用类型在生物学过程和疾病发展中的功能多样性，并评估了这一令人兴奋的研究领域的新趋势。本文分类如下：RNA与蛋白质及其他分子的相互作用>蛋白质-RNA相互作用：功能影响；RNA与蛋白质及其他分子的相互作用>蛋白质-RNA识别；RNA加工>RNA编辑与修饰。
