Vocational Health College, Canakkale Onsekiz Mart University, Canakkale, Turkey.
Akershus Universitetssykehus, Medical Department, Lørenskog, Norway.
Wiley Interdiscip Rev RNA. 2022 Jul;13(4):e1702. doi: 10.1002/wrna.1702. Epub 2021 Nov 23.
The field of epitranscriptome, posttranscriptional modifications to RNAs, is still growing up and has presented substantial evidences for the role of RNA modifications in diseases. In terms of new drug development, RNA modifications have a great promise for therapy. For example, more than 170 type of modifications exist in various types of RNAs. Regulatory genes and their roles in critical biological process have been identified and they are associated with several diseases. Current data, for example, identification of inhibitors targeting RNA modifications regulatory genes, strongly support the idea that RNA modifications have potential as emerging therapeutic targets. Therefore, in this review, RNA modifications and regulatory genes were comprehensively documented in terms of drug development by summarizing the findings from previous studies. It was discussed how RNA modifications or regulatory genes can be targeted by altering molecular mechanisms. This article is categorized under: RNA in Disease and Development > RNA in Disease RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications RNA Processing > RNA Editing and Modification.
表观转录组学领域，即 RNA 的转录后修饰，仍在不断发展，并为 RNA 修饰在疾病中的作用提供了大量证据。就新药开发而言，RNA 修饰在治疗方面具有很大的前景。例如，在各种类型的 RNA 中存在超过 170 种类型的修饰。调控基因及其在关键生物过程中的作用已被确定，并与多种疾病相关。例如，目前已经鉴定出针对 RNA 修饰调控基因的抑制剂，这些发现强烈支持 RNA 修饰作为新兴治疗靶点的潜力。因此，在这篇综述中，通过总结以前研究的结果，从药物开发的角度全面记录了 RNA 修饰和调控基因。讨论了如何通过改变分子机制来靶向 RNA 修饰或调控基因。本文属于以下分类：RNA 在疾病和发育中的作用 > RNA 在疾病中 RNA 与蛋白质和其他分子的相互作用 > 蛋白质-RNA 相互作用：功能意义 RNA 加工 > RNA 编辑和修饰。
