Agrawal Shikha, Bablani Popli Deepika, Sircar Keya, Chowdhry Aman
Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India.
Dept of Oral Pathology and Microbiology, Faculty of Dentistry, JMI, New Delhi, India.
J Oral Biol Craniofac Res. 2020 Apr-Jun;10(2):206-209. doi: 10.1016/j.jobcr.2020.04.007. Epub 2020 Apr 18.
Azadirachta indica (neem), belongs to the family of Meliaceae plants, is found in the Indian subcontinent. The neem tree is colloquially referred to as the village pharmacy due to its array of biological properties. Every part of the neem tree like its bark, leaves, sap, fruit, seeds, and twigs find a multitude of uses. It is customary to use them for management of skin diseases and various other infections.The anticancer properties of neem have been studied in the past and these include its ability to modulate the tumour environment, increase the cytotoxic ability of host monocytes and suppress the proliferation of tumour cells. The present review was conducted with the objective of scrutinizing and assimilating data about the usefulness Azadirachta indica in oral cancer from all the previously done work.
A planned review was conducted of all the studies that investigated the role of Azadirachta indica in oral cancer. Literature search was carried out using PubMed, Scopus and Google scholar databases. In addition to electronic searching, hand searching, cross referencing and various internet engines were also used to collect data. The articles were perused and articles not pertinent to our search were omitted.
The anticancer properties of neem were evaluated and the active constituents of neem have been demonstrated to unequivocally have preventive and therapeutic potential against oral cancer. Although, greater exploration of the anticancer properties of neem are required in order to effectively integrate it into the routine management of oral cancer.
印楝属于楝科植物，生长于印度次大陆。由于其具有一系列生物学特性，印楝树被通俗地称为乡村药房。印楝树的各个部分，如树皮、树叶、树液、果实、种子和嫩枝都有多种用途。人们习惯用它们来治疗皮肤病和各种其他感染。过去已经对印楝的抗癌特性进行了研究，这些特性包括其调节肿瘤环境的能力、增强宿主单核细胞的细胞毒性能力以及抑制肿瘤细胞的增殖。本综述的目的是审查和整理此前所有关于印楝在口腔癌方面有用性的数据。
对所有研究印楝在口腔癌中作用的研究进行了有计划的综述。使用PubMed、Scopus和谷歌学术数据库进行文献检索。除了电子检索外，还通过手工检索、交叉引用和各种互联网引擎来收集数据。仔细阅读文章，省略与我们的检索无关的文章。
对印楝的抗癌特性进行了评估，已证明印楝的活性成分明确具有预防和治疗口腔癌的潜力。然而，为了有效地将其纳入口腔癌的常规治疗，还需要对印楝的抗癌特性进行更深入的探索。
