Batra Neelu, Kumar Vigneshwari Easwar, Nambiar Roshni, De Souza Cristabelle, Yuen Ashley, Le Uyen, Verma Rashmi, Ghosh Paramita M, Vinall Ruth L
Department of Pharmaceutical & Biomedical Sciences, California Northstate University College of Pharmacy, Elk Grove, CA, USA.
Department of Biochemistry and Molecular Medicine, University of California Davis Comprehensive Cancer Center, Sacramento, CA, USA.
Ann Transl Med. 2022 Jul;10(13):754. doi: 10.21037/atm-22-94.
Multiple studies have demonstrated the medical potency of plant extracts and specific phytochemicals as therapeutics for prostate cancer (PCa) patients. Of note, the Neem plant known for its role as an antibiotic and anti-inflammatory is underexplored with an untapped potential for further development. This review focuses on extracts and phytochemicals derived from the Neem tree (Latin name; ), commonly used throughout Southeast Asia for the prevention and treatment of a wide array of diseases including cancer. To date, there are more than 130 biologically active compounds that have been isolated from the Neem tree including azadirachtin, nimbolinin, nimbin, nimbidin, nimbidol, which have demonstrated a wide range of biological activities including anti-microbial, anti-fertility, anti-inflammatory, anti-arthritic, hepatoprotective, anti-diabetic, anti-ulcer, and anti-cancer effects. Very few scientific reports focus on the benefits of Neem in PCa, even though this herb has been used to prevent the disease and its progression for years in complementary and alternative medicine.
We used the search engines like PubMed, InCommon and Google using the key words: "Neem", "Cancer", "Prostate Cancer" and related words to find the information and data within the time frame from 1980-2022 for our article study.
Here, we provide an overview of Neem extracts and phytochemical derivatives with a focus on their known potential and ability to inhibit specific cellular signaling pathways and processes which drive PCa incidence and progression.
The information presented here indicate that Neem and its derivatives have a therapeutic potential for the treatment of PCa when used as a single agent or in combination with conventional chemotherapeutics.
多项研究已证明植物提取物和特定植物化学物质对前列腺癌（PCa）患者具有医学疗效。值得注意的是，以抗生素和抗炎作用著称的印楝树在这方面的研究较少，具有尚未开发的进一步发展潜力。本综述聚焦于从印楝树（拉丁名： ）中提取的提取物和植物化学物质，印楝树在东南亚广泛用于预防和治疗包括癌症在内的多种疾病。迄今为止，已从印楝树中分离出130多种生物活性化合物，包括印楝素、尼姆比林、印楝宁、印楝定、印楝醇，它们具有广泛的生物活性，包括抗菌、抗生育、抗炎、抗关节炎、保肝、抗糖尿病、抗溃疡和抗癌作用。尽管这种草药多年来一直在补充和替代医学中用于预防疾病及其进展，但很少有科学报告关注印楝对前列腺癌的益处。
我们使用PubMed、InCommon和谷歌等搜索引擎，使用关键词“印楝”、“癌症”、“前列腺癌”及相关词汇，在1980 - 20
