Miller Danny E, Ferreira Carlos R, Scott Anna I, Chang Irene J
Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Washington, USA.
Department of Pediatrics, Division of Genetic Medicine, University of Washington, Seattle, Washinghton and Seattle Children's Hospital, Seattle, Washington, USA.
Mol Genet Metab Rep. 2020 May 22;24:100607. doi: 10.1016/j.ymgmr.2020.100607. eCollection 2020 Sep.
Serine, a non-essential amino acid, has attracted clinical attention because of potential benefit in certain metabolic and neurological disorders. Despite the therapeutic potential, little is known about the pharmacokinetics of l-serine metabolism in humans. Here we present pharmacokinetic data at the time of treatment initiation as well as plasma serine levels during dose escalation from a single individual taking oral l-serine as part of a treatment regimen. Our results show that plasma serine levels rise and fall rapidly after oral l-serine intake, suggesting that the optimal dosing for oral l-serine supplementation is at least three times per day.
丝氨酸是一种非必需氨基酸，因其在某些代谢和神经疾病中具有潜在益处而受到临床关注。尽管具有治疗潜力，但关于人体中左旋丝氨酸代谢的药代动力学却知之甚少。在此，我们展示了一名接受口服左旋丝氨酸作为治疗方案一部分的个体在开始治疗时的药代动力学数据以及剂量递增期间的血浆丝氨酸水平。我们的结果表明，口服左旋丝氨酸后，血浆丝氨酸水平迅速上升和下降，这表明口服补充左旋丝氨酸的最佳给药频率至少为每天三次。
