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伴有内脏转移及p16/人乳头瘤病毒阳性的阴茎癌:一例长期生存的罕见病例

Penile cancer with visceral metastasis and p16/human papillomavirus positivity: An unusual case of long-term survival.

作者信息

Mehra Nandini S, Ho Thanh P, Herrera Hernandez Loren, Quevedo J Fernando, Costello Brian A, Pagliaro Lance C

机构信息

Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

出版信息

Urol Case Rep. 2020 May 24;33:101278. doi: 10.1016/j.eucr.2020.101278. eCollection 2020 Nov.

DOI:10.1016/j.eucr.2020.101278
PMID:32489901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7260682/
Abstract

Squamous cell carcinoma (SCC) of the penis is a rare cancer in the industrialized countries, including the United States. Risk factors for these cancers include inflammatory conditions as well as infection with the human papilloma virus (HPV). Treatment modalities are based on TNM staging and may include surgical management or chemoradiation. Patients with local or some regional disease can have a favorable prognosis; however, with extranodal metastasis, survival decreases sharply. Here, we present a case of long-term disease-free survival in a patient with widely metastatic SCC of the penis.

摘要

阴茎鳞状细胞癌(SCC)在包括美国在内的工业化国家是一种罕见的癌症。这些癌症的风险因素包括炎症性疾病以及人乳头瘤病毒(HPV)感染。治疗方式基于TNM分期,可能包括手术治疗或放化疗。局部或某些区域疾病的患者预后可能较好;然而,出现结外转移时,生存率会急剧下降。在此,我们报告一例阴茎广泛转移性SCC患者长期无病生存的病例。

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A Changing of the Guard: Immune Checkpoint Inhibitors With and Without Chemotherapy as First Line Treatment for Metastatic Non-small Cell Lung Cancer.交接班:免疫检查点抑制剂联合或不联合化疗作为转移性非小细胞肺癌一线治疗方案
Front Oncol. 2019 Mar 29;9:195. doi: 10.3389/fonc.2019.00195. eCollection 2019.
2
Prognostic Significance of HPV and p16 Status in Men Diagnosed with Penile Cancer: A Systematic Review and Meta-analysis.HPV 和 p16 状态在诊断为阴茎癌的男性中的预后意义:系统评价和荟萃分析。
Cancer Epidemiol Biomarkers Prev. 2018 Oct;27(10):1123-1132. doi: 10.1158/1055-9965.EPI-18-0322. Epub 2018 Jul 9.
3
Treatment for Metastatic Penile Cancer After First-line Chemotherapy Failure: Analysis of Response and Survival Outcomes.
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Urology. 2015 May;85(5):1104-1110. doi: 10.1016/j.urology.2014.12.049. Epub 2015 Mar 25.
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J Clin Oncol. 2010 Aug 20;28(24):3851-7. doi: 10.1200/JCO.2010.29.5477. Epub 2010 Jul 12.
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J Urol. 2010 Jun;183(6):2227-32. doi: 10.1016/j.juro.2010.02.025.