Centro de Estudios e Investigación de la Enfermedad de Chagas y Leishmaniasis, FCM, INICSA-CONICET-UNC, Córdoba, Argentina.
Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS Granada, Granada, España.
Acta Trop. 2020 Oct;210:105546. doi: 10.1016/j.actatropica.2020.105546. Epub 2020 May 31.
The aim of the present study was to analyze IL6 rs1800795 genetic variant in the susceptibility to Trypanosoma cruzi infection and in the development of chronic Chagas cardiomyopathy (CCC), in five independent Latin American cohorts. A total of 3,087 individuals from Latin American countries (Argentina, Bolivia, Peru, and two cohorts from Colombia) were studied. In all cohorts, patients were classified as seropositive for T. cruzi antigens (n= 1,963) and seronegative (n= 1,124). Based on clinical evaluation, the seropositive patients, were classified as CCC (n= 900) and asymptomatic (n= 1,063). No statistically significant differences in the frequency of IL6 rs1800795 between seropositive and seronegative, or between CCC and asymptomatic patients, were found. Furthermore, after the meta-analysis no statistically significant differences were observed. Our results do not support a contribution of IL6 rs1800795 genetic variant in the susceptibility to the infection and the development of chronic Chagas cardiomyopathy in the studied populations.
本研究旨在分析白细胞介素 6(rs1800795) 基因变异在感染克氏锥虫和慢性恰加斯心肌病（CCC）易感性中的作用，研究对象来自五个独立的拉丁美洲队列。共纳入来自拉丁美洲国家（阿根廷、玻利维亚、秘鲁和哥伦比亚的两个队列）的 3087 名个体。在所有队列中，根据 T. cruzi 抗原的血清学检测结果将患者分为阳性（n=1963）和阴性（n=1124）。基于临床评估，将血清阳性患者分为 CCC（n=900）和无症状（n=1063）。未发现 IL6 rs1800795 基因频率在血清阳性和阴性患者之间或 CCC 和无症状患者之间存在统计学差异。此外，荟萃分析后也未观察到统计学差异。我们的结果不支持 IL6 rs1800795 基因变异在研究人群中对感染和慢性恰加斯心肌病易感性的作用。
