Pharmacognosy and Phytochemistry Laboratory, Faculty of Pharmacy, VNS Group of Institutions, VNS Campus, Vidya Vihar, Neelbad-462044, Bhopal, MP, India.
Ravi Shankar College of Pharmacy, Bypass Road, Bhanpur Square, Bhopal, MP 462010, India.
Pharmacol Res. 2020 Sep;159:104925. doi: 10.1016/j.phrs.2020.104925. Epub 2020 May 31.
Adaptive cellular stress response confers stress tolerance against inflammatory and metabolic disorders. In response to metabolic stress, the key mediator of cellular adaptation and tolerance is a class of molecules called the molecular chaperones (MCs). MCs are highly conserved molecules that play critical role in maintaining protein stability and functionality. Hormesis in this context is a unique adaptation mechanism where a low dose of a stressor (which is toxic at high dose) confers a stress-resistant adaptive cellular phenotype. Hormesis can be observed at different level of biological organization at various measurable endpoints. The MCs are believed to play a key role in adaptation during hormesis. Several phytochemicals are known for their hormetic response and are called phytochemical hormetins. The role of phytochemical-mediated hormesis on the adaptive cellular processes is proposed as a potential therapeutic approach to target inflammation associated with metabolic syndrome. However, the screening of phytochemical hormetins would require a paradigm shift in the methods currently used in drug discovery.
适应性细胞应激反应赋予了细胞对炎症和代谢紊乱的耐受能力。在应对代谢应激时，细胞适应和耐受的关键介质是一类被称为分子伴侣（MCs）的分子。MCs 是高度保守的分子，在维持蛋白质稳定性和功能方面发挥着关键作用。在这种情况下，应激反应是一种独特的适应机制，其中低剂量的应激源（高剂量时有毒）赋予了细胞应激抗性的适应性表型。应激反应可以在不同的生物学组织水平和各种可测量的终点上观察到。MCs 被认为在应激反应中发挥着关键作用。一些植物化学物质因其应激反应而被称为植物化学应激素。植物化学物质介导的应激反应对适应性细胞过程的作用被提出作为一种潜在的治疗方法，以靶向与代谢综合征相关的炎症。然而，植物化学应激素的筛选需要在目前用于药物发现的方法上进行范式转变。
